Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old.
Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old.
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DOI：
10.1016/j.bja.2018.01.037
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发表时间：
2018-06
影响因子：
9.8
通讯作者：
Berde CB
中科院分区：
文献类型：
--
作者：
Cornelissen L;Kim SE;Lee JM;Brown EN;Purdon PL;Berde CB
全身麻醉剂在脑电图（EEG）中产生与神经回路结构密切相关的具有空间定义的脑电波振荡。关于儿童全身麻醉的神经回路活动的详细研究很少。本研究旨在确定在七氟烷麻醉期间反映人类早期大脑发育不同阶段的脑电图特征的年龄相关变化。
对91名0 - 3岁接受择期手术的儿童进行了多通道脑电图记录。我们绘制了在维持麻醉期间额叶、顶叶、颞叶和枕叶皮质的空间功率和相干性图谱。
在七氟烷作用期间：（i）所有年龄段都存在慢 - δ（0.1 - 4Hz）振荡；（ii）约4个月时出现θ（4 - 8Hz）和α（8 - 12Hz）振荡；（iii）α振荡功率从4个月到10个月增加；（iv）约6个月时出现额叶α振荡优势；（v）额叶慢振荡从出生到6个月是相干的；（vi）额叶α振荡在约10个月时变得相干，并在更大年龄持续存在。
丘脑 - 皮质回路成熟过程中的关键发育里程碑可能导致接受七氟烷全身麻醉的婴儿脑电图模式发生变化。儿童麻醉诱导的脑电图振荡特征表明，制定依赖年龄的策略以正确监测接受全身麻醉的儿童的大脑状态非常重要。这些数据有可能指导未来对涉及兴奋性 - 抑制性平衡改变的神经发育病理学的研究，如癫痫或瑞特综合征。
General anaesthetics generate spatially defined brain oscillations in the EEG that relate fundamentally to neural-circuit architecture. Few studies detailing the neural-circuit activity of general anaesthesia in children have been described. The study aim was to identify age-related changes in EEG characteristics that mirror different stages of early human brain development during sevoflurane anaesthesia. Multichannel EEG recordings were performed in 91 children aged 0–3 yr undergoing elective surgery. We mapped spatial power and coherence over the frontal, parietal, temporal, and occipital cortices during maintenance anaesthesia. During sevoflurane exposure: (i) slow–delta (0.1–4 Hz) oscillations were present in all ages, (ii) theta (4–8 Hz) and alpha (8–12 Hz) oscillations emerge by ∼4 months, (iii) alpha oscillations increased in power from 4 to 10 months, (iv) frontal alpha-oscillation predominance emerged at ∼6 months, (v) frontal slow oscillations were coherent from birth until 6 months, and (vi) frontal alpha oscillations became coherent ∼10 months and persisted in older ages. Key developmental milestones in the maturation of the thalamo-cortical circuitry likely generate changes in EEG patterns in infants undergoing sevoflurane general anaesthesia. Characterisation of anaesthesia-induced EEG oscillations in children demonstrates the importance of developing age-dependent strategies to monitor properly the brain states of children receiving general anaesthesia. These data have the potential to guide future studies investigating neurodevelopmental pathologies involving altered excitatory–inhibitory balance, such as epilepsy or Rett syndrome.
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影响因子：
8.8
作者：
Blain-Moraes S;Tarnal V;Vanini G;Alexander A;Rosen D;Shortal B;Janke E;Mashour GA
通讯作者：
Mashour GA
影响因子：
3
作者：
Hight, Darren;Voss, Logan J.;Sleigh, Jamie
通讯作者：
Sleigh, Jamie
婴儿七氟硫素全身麻醉期间年龄依赖性的脑电图（EEG）模式。
影响因子：
7.7
作者：
Cornelissen L;Kim SE;Purdon PL;Brown EN;Berde CB
通讯作者：
Berde CB
DOI：
10.1073/pnas.1017069108
发表时间：
2010-12-28
影响因子：
11.1
作者：
Ching, ShiNung;Cimenser, Aylin;Kopell, Nancy J.
通讯作者：
Kopell, Nancy J.
影响因子：
9.8
作者：
Gaskell, A. L.;Hight, D. F.;Sanders, R. D.
通讯作者：
Sanders, R. D.