Application of dose-addition analyses to characterize the abuse-related effects of drug mixtures.
Application of dose-addition analyses to characterize the abuse-related effects of drug mixtures.
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DOI：
10.1002/jeab.741
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发表时间：
2022-05
影响因子：
2.7
通讯作者：
Collins, Gregory T.
中科院分区：
文献类型：
--
作者：
Doyle, Michelle R.;Gannon, Brenda M.;Mesmin, Melson P.;Collins, Gregory T.
多种药物的使用占药物使用的大部分，但调查药物混合物滥用相关影响的研究相对较少。剂量加成分析提供了一种严格的定量方法来确定两种或多种药物之间相互作用的性质（即超加成、加成或亚加成）。正如此处简要回顾的那样，恒河猴的研究已将剂量添加分析应用于群体水平数据，以表征兴奋剂和阿片类药物（例如可卡因 + 海洛因的混合物）增强作用之间相互作用的性质。在这些基础研究的基础上，最近的工作应用了剂量添加分析，以更好地了解咖啡因与非法兴奋剂（如 MDPV 和甲基苯丙胺）在大鼠体内相互作用的性质。除了利用各种操作程序（包括药物区分、药物自我给药和药物启动恢复）之外，这些研究还纳入了效力和有效性比率，作为统计分析和可视化群体和个体受试者水平上的可加性偏差的方法。因此，剂量添加分析代表了一种强大且未充分利用的方法来量化药物相互作用的性质，可应用于各种滥用相关的终点，以便更好地了解多物质使用的行为药理学。
Polysubstance use makes up a majority of drug use, yet relatively few studies investigate the abuse-related effects of drug mixtures. Dose-addition analyses provide a rigorous and quantitative method to determine the nature of the interaction (i.e., supra-additive, additive, or sub-additive) between two or more drugs. As briefly reviewed here, studies in rhesus monkeys have applied dose-addition analyses to group level data to characterize the nature of the interaction between the reinforcing effects of stimulants and opioids (e.g., mixtures of cocaine + heroin). Building upon these foundational studies, more recent work has applied dose-addition analyses to better understand the nature of the interaction between caffeine and illicit stimulants such as MDPV and methamphetamine in rats. In addition to utilizing a variety of operant procedures, including drug discrimination, drug self-administration, and drug-primed reinstatement, these studies have incorporated potency and effectiveness ratios as a method for both statistical analysis and visualization of departures from additivity at both the group and individual subject level. As such, dose-addition analyses represent a powerful and underutilized approach to quantify the nature of drug-drug interactions that can be applied to a variety of abuse-related endpoints in order to better understand the behavioral pharmacology of polysubstance use.
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影响因子：
7.6
作者：
Gannon, Brenda M.;Galindo, Kayla I.;Collins, Gregory T.
通讯作者：
Collins, Gregory T.
DOI：
10.1016/j.pbb.2021.173112
发表时间：
2021-03
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
de Moura FB;Sherwood A;Prisinzano TE;Paronis CA;Bergman J;Kohut SJ
通讯作者：
Kohut SJ
影响因子：
7.6
作者：
Gannon, Brenda M.;Baumann, Michael H.;Collins, Gregory T.
通讯作者：
Collins, Gregory T.
影响因子：
12.7
作者：
Cicero, Theodore J.;Ellis, Matthew S.;Kasper, Zachary A.
通讯作者：
Kasper, Zachary A.
影响因子：
3.6
作者：
Briscoe, RJ;Vanecek, SA;Gauvin, DV
通讯作者：
Gauvin, DV