Retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma.
Retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma.
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DOI：
10.1001/archophthalmol.2011.352
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发表时间：
2011-12
影响因子：
--
通讯作者：
Hood, Donald C.
中科院分区：
文献类型：
--
作者：
Raza, Ali S.;Cho, Jungsuk;de Moraes, Carlos G. V.;Wang, Min;Zhang, Xian;Kardon, Randy H.;Liebmann, Jeffrey M.;Ritch, Robert;Hood, Donald C.
目的：比较标准自动视野计(SAP)测量的敏感度损失与频域光学相干断层扫描(OCT)测量的局部视网膜神经节细胞层(RGC)厚度在青光眼患者黄斑中的差异。为了比较14例青光眼患者和19例对照组的RGC厚度与10-2SAP的总偏差(Td)的对应位置，一位经验丰富的操作员手动纠正了128张水平B超的RGC和内丛状层(RGC+IPL)的自动分割。为了解释中心凹周围RGC小体的移位，根据已发表的组织学结果，SAP测试点的位置被调整为与RGC小体的位置相对应，而不是与光感受器相对应。为了进行分析，RGC+IPL厚度与SAP(TD)的数据被分成5个偏心点，从视网膜相对于中心凹半径3.4°到9.7°。RGC+IPL厚度与中心凹约7.2°范围内的SAP丢失有良好的相关性(Spearmanρ=0.71~0.74)。在正常RGC层较薄的7.2°以上，一致性较差(0.53~0.65)。RGC+IPL厚度与SAP线性损失之间的线性模型对7.2°范围内的偏心率提供了合理的拟合。在中央7.2°，当校正RGC移位时，局部RGC+IPL厚度与青光眼局部敏感度丧失有很好的相关性。
To compare loss in sensitivity measured using standard automated perimetry (SAP) with local retinal ganglion cell layer (RGC) thickness measured using frequency-domain optical coherence tomography in the macula of patients with glaucoma. To compare corresponding locations of RGC thickness with total deviation (TD) of 10-2 SAP for 14 patients with glaucoma and 19 controls, an experienced operator hand-corrected automatic segmentation of the combined RGC and inner plexiform layer (RGC + IPL) of 128 horizontal B-scans. To account for displacement of the RGC bodies around the fovea, the location of the SAP test points was adjusted to correspond to the location of the RGC bodies rather than to the photoreceptors, based on published histological findings. For analysis, RGC + IPL thickness vs SAP (TD) data were grouped into 5 eccentricities, from 3.4° to 9.7° radius on the retina with respect to the fovea. The RGC + IPL thickness correlated well with SAP loss within approximately 7.2° of the fovea (Spearman ρ = 0.71–0.74). Agreement was worse (0.53–0.65) beyond 7.2°, where the normal RGC layer is relatively thin. A linear model relating RGC + IPL thickness to linear SAP loss provided a reasonable fit for eccentricities within 7.2°. In the central 7.2°, local RGC + IPL thickness correlated well with local sensitivity loss in glaucoma when the data were adjusted for RGC displacement.
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影响因子：
4.4
作者：
Hood DC;Anderson SC;Wall M;Raza AS;Kardon RH
通讯作者：
Kardon RH
影响因子：
1.4
作者：
Drasdo, Neville;Mortlock, Katharine E.;North, Rachel V.
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North, Rachel V.
影响因子：
4.4
作者：
Hood, Donald C.;Raza, Ali S.;Ritch, Robert
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Ritch, Robert
影响因子：
4.4
作者：
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通讯作者：
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影响因子：
4.4
作者：
Leung, CKS;Chong, KKL;Yung, WH
通讯作者：
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