A functional Ser326Cys polymorphism in hOGG1 is associated with noise-induced hearing loss in a Chinese population.
A functional Ser326Cys polymorphism in hOGG1 is associated with noise-induced hearing loss in a Chinese population.
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HOGG1中的功能性SER326CYS多态性与中国人群的噪声引起的听力损失有关。
DOI：
10.1371/journal.pone.0089662
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhu B
中科院分区：
文献类型：
--
作者：
Shen H;Cao J;Hong Z;Liu K;Shi J;Ding L;Zhang H;Du C;Li Q;Zhang Z;Zhu B
8-氧代鸟嘌呤（8-oxoG）对耳蜗毛细胞的DNA损伤是噪声性听力损失（NIHL）发生的关键。人8-oxoG DNA糖基化酶1（hOGG 1）是消除8-oxoG的碱基切除修复（BER）途径中的关键酶。许多流行病学和功能研究表明，hOGG 1 Ser 326 Cys多态性（rs 1052133）与许多疾病相关。本研究的目的是探讨人类BER通路中hOGG 1 Ser 326 Cys多态性是否与中国人群NIHL的遗传易感性相关。对612名NIHL工人和615名听力正常工人进行了基因分型。我们发现，与hOGG 1 Ser/Ser基因型个体相比，hOGG 1 Cys/Cys基因型个体发生NIHL的风险显著增加（校正OR = 1.59，95%CI = 1.13-2.25），并且在15- 25年和>25年的噪声暴露时间、85-92 dB（A）噪声暴露水平、曾经吸烟、在隐性模型中也观察到了类似的效应。总之，我们的数据表明，hOGG 1 Cys/Cys基因型可能是一个遗传易感性标记的NIHL在中国汉族人群。
DNA damage to cochlear hair cells caused by 8-oxoguanine (8-oxoG) is essential for the development of noise-induced hearing loss (NIHL). Human 8-oxoG DNA glycosylase1 (hOGG1) is a key enzyme in the base excision repair (BER) pathway that eliminates 8-oxoG. Many epidemiological and functional studies have suggested that the hOGG1 Ser326Cys polymorphism (rs1052133) is associated with many diseases. The purpose of this investigation was to investigate whether the hOGG1 Ser326Cys polymorphism in the human BER pathway is associated with genetic susceptibility to NIHL in a Chinese population. This polymorphism was genotyped among 612 workers with NIHL and 615 workers with normal hearing. We found that individuals with the hOGG1 Cys/Cys genotype had a statistically significantly increased risk of NIHL compared with those who carried the hOGG1 Ser/Ser genotype (adjusted OR = 1.59, 95% CI = 1.13–2.25) and this increased risk was more pronounced among the workers in the 15- to 25- and >25-year noise exposure time, 85–92 dB(A) noise exposure level, ever smoking, and ever drinking groups, similar effects were also observed in a recessive model. In summary, our data suggested that the hOGG1 Cys/Cys genotype may be a genetic susceptibility marker for NIHL in the Chinese Han population.
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影响因子：
14.9
作者：
Hill JW;Evans MK
通讯作者：
Evans MK
影响因子：
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作者：
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作者：
Jiao, Xingyuan;Huang, Jiefu;Su, Xiaokang
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Mizoue, T;Miyamoto, T;Shimizu, T
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Shimizu, T
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影响因子：
5.7
作者：
Li, Qian;Huang, Lizhen;Fang, Yongjun
通讯作者：
Fang, Yongjun