Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate through Non-Apoptotic Cell Death?
Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate through Non-Apoptotic Cell Death?
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DOI：
10.3390/biomedicines11102792
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发表时间：
2023-10-14
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
胰腺导管腺癌（PDAC）是一种实体瘤，其特点是预后不良和对治疗有抵抗力。抗凋亡、细胞死亡过程和抗凋亡机制是癌症的一些标志。探索非凋亡细胞死亡机制为克服 PDAC 的细胞凋亡抵抗提供了机会。最近的几项研究评估了铁死亡、坏死性凋亡和焦亡作为 PDAC 中的非凋亡细胞死亡过程，在该疾病的预后和治疗中发挥着至关重要的作用。铁死亡、坏死性凋亡和焦亡通过多种信号通路、基因表达和免疫调节在 PDAC 发育中发挥着至关重要的作用。本综述总结了目前对铁死亡、坏死性凋亡和焦亡如何与信号通路、基因组、免疫系统、代谢和 PDAC 预后和治疗中的其他因素相互作用的理解。
Pancreatic ductal adenocarcinoma (PDAC) is a solid tumor characterized by poor prognosis and resistance to treatment. Resistance to apoptosis, a cell death process, and anti-apoptotic mechanisms, are some of the hallmarks of cancer. Exploring non-apoptotic cell death mechanisms provides an opportunity to overcome apoptosis resistance in PDAC. Several recent studies evaluated ferroptosis, necroptosis, and pyroptosis as the non-apoptotic cell death processes in PDAC that play a crucial role in the prognosis and treatment of this disease. Ferroptosis, necroptosis, and pyroptosis play a crucial role in PDAC development via several signaling pathways, gene expression, and immunity regulation. This review summarizes the current understanding of how ferroptosis, necroptosis, and pyroptosis interact with signaling pathways, the genome, the immune system, the metabolism, and other factors in the prognosis and treatment of PDAC.
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影响因子：
5.8
作者：
Nayak, Debasis;Weadick, Brenna;Persaud, Avinash K.;Raj, Radhika;Shakya, Reena;Li, Junan;Campbell, Moray J.;Govindarajan, Rajgopal
通讯作者：
Govindarajan, Rajgopal
影响因子：
4.7
作者：
Zhang, Jing;You, Xiaomin;Kang, Dong;Zhou, Guoxiong
通讯作者：
Zhou, Guoxiong
DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
3.6
作者：
Xu, Xiang;Liang, Jia-Hua;Li, Jian-Hui;Xu, Qiong-Cong;Yin, Xiao-Yu
通讯作者：
Yin, Xiao-Yu
DOI：
10.1126/science.aaw9872
发表时间：
2020-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badgley MA;Kremer DM;Maurer HC;DelGiorno KE;Lee HJ;Purohit V;Sagalovskiy IR;Ma A;Kapilian J;Firl CEM;Decker AR;Sastra SA;Palermo CF;Andrade LR;Sajjakulnukit P;Zhang L;Tolstyka ZP;Hirschhorn T;Lamb C;Liu T;Gu W;Seeley ES;Stone E;Georgiou G;Manor U;Iuga A;Wahl GM;Stockwell BR;Lyssiotis CA;Olive KP
通讯作者：
Olive KP