The CATH hierarchy revisited-structural divergence in domain superfamilies and the continuity of fold space.
The CATH hierarchy revisited-structural divergence in domain superfamilies and the continuity of fold space.
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DOI：
10.1016/j.str.2009.06.015
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发表时间：
2009-08-12
期刊：
影响因子：
--
通讯作者：
Orengo C
中科院分区：
文献类型：
--
作者：
Cuff A;Redfern OC;Greene L;Sillitoe I;Lewis T;Dibley M;Reid A;Pearl F;Dallman T;Todd A;Garratt R;Thornton J;Orengo C
本文探讨了CATH的结构连续性以及超家族采用不同褶皱的程度。尽管大多数超科在结构上是保守的，但在一些人口最多的超科（占所有超科的4%）中，存在相当大的结构分歧。虽然近亲在进化保守的核心中具有相似的褶皱，但对该核心的不同阐述可能导致全球结构的显着差异。应用类似的协议来检查不同折叠组之间结构重叠的程度，似乎这种影响仅限于少数结构，并且主要是由于小的，反复出现的超次级基序（例如，αβ-基序，α-发夹）。虽然24%的超家族与具有不同褶皱的超家族重叠，但CATH中只有14%的非冗余结构涉及重叠。然而，这些重叠的存在表明，在结构空间的某些区域，折叠宇宙应该被视为更连续的。
This paper explores the structural continuum in CATH and the extent to which superfamilies adopt distinct folds. Although most superfamilies are structurally conserved, in some of the most highly populated superfamilies (4% of all superfamilies) there is considerable structural divergence. While relatives share a similar fold in the evolutionary conserved core, diverse elaborations to this core can result in significant differences in the global structures. Applying similar protocols to examine the extent to which structural overlaps occur between different fold groups, it appears this effect is confined to just a few architectures and is largely due to small, recurring super-secondary motifs (e.g., αβ-motifs, α-hairpins). Although 24% of superfamilies overlap with superfamilies having different folds, only 14% of nonredundant structures in CATH are involved in overlaps. Nevertheless, the existence of these overlaps suggests that, in some regions of structure space, the fold universe should be seen as more continuous.
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DOI：
10.1107/s0907444998009172
发表时间：
1998-11-01
期刊：
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
影响因子：
--
作者：
Hubbard, TJP;Ailey, B;Chothia, C
通讯作者：
Chothia, C
影响因子：
14.9
作者：
Friedberg I;Godzik A
通讯作者：
Godzik A
影响因子：
5.7
作者：
ORENGO, CA;THORNTON, JM
通讯作者：
THORNTON, JM
影响因子：
14.9
作者：
Marsden, RL;Lee, D;Orengo, CA
通讯作者：
Orengo, CA
影响因子：
5.8
作者：
McGuffin, LJ;Bryson, K;Jones, DT
通讯作者：
Jones, DT