The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review.
The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review.
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DOI：
10.1111/j.1530-0277.2011.01633.x
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Anton RF
中科院分区：
文献类型：
--
作者：
Ray LA;Barr CS;Blendy JA;Oslin D;Goldman D;Anton RF
The endogenous opioid system has been implicated in the pathophysiology of alcoholism as it modulates the neurobehavioral effects of alcohol. A variant in the mu opioid receptor gene (OPRM1), the Asn40Asp polymorphism, has received attention as a functional variant that may influence a host of behavioral phenotypes for alcoholism as well as clinical response to opioid antagonists. This paper will review converging lines of evidence on the effect of the Asn40Asp SNP on alcoholism phenotypes, including: (i) genetic association studies; (ii) behavioral studies of alcoholism; (iii) neuroimaging studies; (iv) pharmacogenetic studies and clinical trials; and (v) preclinical animal studies. Together, these lines of research seek to elucidate the effects of this functional polymorphism on alcoholism etiology and treatment response.
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影响因子：
4.7
作者：
Beyer, A;Koch, T;Höllt, V
通讯作者：
Höllt, V
影响因子：
3.6
作者：
Boettiger, Charlotte A.;Kelley, Elizabeth A.;Mitchell, Jennifer M.;D'Esposito, Mark;Fields, Howard L.
通讯作者：
Fields, Howard L.
DOI：
10.15288/jsas.2005.s15.56
发表时间：
2005-07-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Goldman, D;Oroszi, G;Anton, R
通讯作者：
Anton, R
影响因子：
5.3
作者：
Gelernter J;Kranzler HR
通讯作者：
Kranzler HR
影响因子：
10.6
作者：
Barr CS;Chen SA;Schwandt ML;Lindell SG;Sun H;Suomi SJ;Heilig M
通讯作者：
Heilig M