Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network.
Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network.
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DOI：
10.1016/j.pbb.2009.02.008
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发表时间：
2009-09
影响因子：
3.6
通讯作者：
Fields, Howard L.
中科院分区：
文献类型：
--
作者：
Boettiger, Charlotte A.;Kelley, Elizabeth A.;Mitchell, Jennifer M.;D'Esposito, Mark;Fields, Howard L.
在此之前，我们发现不同的大脑区域预测了个体在小的即时奖励（“现在”）和大的延迟奖励（“以后”）之间的选择偏差。此外，这种选择偏倚可以通过内源性阿片样物质阻断来操纵。为了测试用纳洛酮（NTX）阻断内源性阿片类药物是否会改变预测个体偏差的决策过程中的大脑活动，我们比较了NTX（50 mg）或安慰剂急性给药后与现在与以后决策相关的fMRI BOLD信号。我们在一个双盲的两次会议设计中测试了戒酒者和对照组。我们定义的兴趣区（ROI）的激活峰预测现在与以后的选择偏差为中心。NTX给药显著增加了右侧眶回ROI中决策过程中的BOLD信号，该区域在决策过程中增强的活动预测了后期偏差。探索性分析确定了决策过程中BOLD信号被NTX增强（左眶额皮质、左颞下回和小脑）或降低（右上级颞极）的其他位点。额外的分析确定的网站，包括右侧眶回，其中NTX的BOLD信号预测NTX的选择偏差的影响。这些数据与阿片受体在人类额叶和颞叶皮质的表达一致，并提出了NTX治疗作用的可能机制。
Previously, we found that distinct brain areas predict individual selection bias in decisions between small immediate (“Now”) and larger delayed rewards (“Later”). Furthermore, such selection bias can be manipulated by endogenous opioid blockade. To test whether blocking endogenous opioids with Naltrexone (NTX) alters brain activity during decision-making in areas predicting individual bias, we compared fMRI BOLD signal correlated with Now versus Later decision-making after acute administration of NTX (50 mg) or placebo. We tested abstinent alcoholics and control subjects in a double-blind two-session design. We defined regions of interest (ROI) centered on activation peaks predicting Now versus Later selection bias. NTX administration significantly increased BOLD signal during decision-making in the right lateral orbital gyrus ROI, an area where enhanced activity during decision-making predicts Later bias. Exploratory analyses identified additional loci where BOLD signal during decision-making was enhanced (left orbitofrontal cortex, left inferior temporal gyrus, and cerebellum) or reduced (right superior temporal pole) by NTX. Additional analyses identified sites, including the right lateral orbital gyrus, in which NTX effects on BOLD signal predicted NTX effects on selection bias. These data agree with opioid receptor expression in human frontal and temporal cortices, and suggest possible mechanisms of NTX’s therapeutic effects.
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影响因子：
2.3
作者：
DELARBOL, JL;AGUIRRE, JC;MIRANDA, MT
通讯作者：
MIRANDA, MT
影响因子：
5.3
作者：
Boettiger, Charlotte A.;Mitchell, Jennifer M.;Fields, Howard L.
通讯作者：
Fields, Howard L.
影响因子：
5.3
作者：
Cools, R;Clark, L;Robbins, TW
通讯作者：
Robbins, TW
DOI：
10.1111/j.1530-0277.2007.00339.x
发表时间：
2007-04-01
影响因子：
3.2
作者：
Gelernter, Joel;Gueorguieva, Ralitza;Krystal, John H.
通讯作者：
Krystal, John H.
影响因子：
--
作者：
Anton, Raymond F.;Oroszi, Gabor;Goldman, David
通讯作者：
Goldman, David