Phenolic polyketides from the co-cultivation of marine-derived Penicillium sp. WC-29-5 and Streptomyces fradiae 007.
Phenolic polyketides from the co-cultivation of marine-derived Penicillium sp. WC-29-5 and Streptomyces fradiae 007.
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来自海洋来源的青霉 WC-29-5 和弗拉迪链霉菌 007 共培养的酚类聚酮化合物
DOI：
10.3390/md12042079
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发表时间：
2014-04-04
期刊：
影响因子：
5.4
通讯作者：
Zhu W
中科院分区：
文献类型：
--
作者：
Wang Y;Wang L;Zhuang Y;Kong F;Zhang C;Zhu W
青霉WC-29-5与草莓链霉菌007共培养产生5个天然产物（1-3、4a和4 b），并通过光谱分析对其进行了分离和表征。有趣的是，发现这些化合物与在离散的真菌和细菌对照中产生的那些不同。其中化合物4a和4 b的绝对构型是首次通过X射线单晶衍射实验和电子圆二色性（ECD）计算确定的。对这些化合物的细胞毒性活性的评价显示，4 b对HL-60和H1975肿瘤细胞具有中度细胞毒性，IC 50值分别为3.73和5.73 μM，而化合物4a对H1975细胞仅具有中度细胞毒性，IC 50值为3.97 μM。
Penicillium sp. WC-29-5 was co-cultured with Streptomyces fradiae 007 to produce five natural products (1–3, 4a and 4b) that were isolated and characterized by spectroscopic analysis. Interestingly, these compounds were found to be different from those produced in discrete fungal and bacterial controls. Among these compounds, the absolute configurations of compounds 4a and 4b were determined for the first time by X-ray single crystal diffraction experiments and electronic circular dichroism (ECD) calculations. An evaluation of the cytotoxic activities of these compounds revealed that 4b was moderately cytotoxic towards HL-60 and H1975 tumor cells with IC50 values of 3.73 and 5.73 µM, respectively, whereas compound 4a was only moderately cytotoxic towards H1975 cells with an IC50 value of 3.97 µM.
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影响因子：
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作者：
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