Development and initial characterization of a high-resolution PET detector module with DOI.
Development and initial characterization of a high-resolution PET detector module with DOI.
复制标题
使用DOI的高分辨率宠物探测器模块的开发和初始表征。
DOI：
10.1088/2057-1976/abbd4f
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发表时间：
2020-11
影响因子：
1.4
通讯作者：
Abbaszadeh S
中科院分区：
文献类型：
--
作者：
Li M;Wang Y;Abbaszadeh S
器官专用PET扫描仪由于其在更高灵敏度、更高图像质量和更低成本方面的优势而变得越来越普遍。这些扫描仪中使用的探测器具有更精细的像素尺寸和交互深度（DOI）能力。这项工作提出了一个LYSO（铈）探测器模块与DOI的能力，有可能扩大到一个高分辨率的小动物或器官专用的PET系统。对于DOI功能，我们实验室先前开发了一个子模块，其中包含一个利用PETsys TOFPET 2专用集成电路（ASIC）的LYSO块检测器。我们扩展了子模块并优化了配置，通过设计高速双读出电缆来保持Samtec连接器之间的原始引脚关系，从而在模块的一侧实现了双读出板的紧凑外壳。模块尺寸为53.8 × 57.8 mm2。每个模块有2 × 2个LYSO块，每个LYSO块由4 × 4个LYSO单元组成，每个LYSO单元包含1 × 1 × 20 mm3 LYSO晶体的6 × 6阵列。将LYSO晶体的四个侧面机械研磨至W14，并对两个端面进行抛光。LYSO晶体的两端光学连接到SiPM用于DOI测量。八个LYSO块的性能，包括能量，定时，和DOI分辨率的特点是与一个单一的LYSO板。使用22 Na源在视场（FOV）内的9个位置测量了两个模块（彼此之间的距离为107.4 mm）的面内和正交面空间分辨率。结果表明，在511 keV、658.03 ± 15.18 ps和2.62 ± 0.06 mm处，所有LYSO块的平均能量、时间和DOI分辨率分别为16.13% ± 1.01%。两个模块的能量和时间分辨率分别为16.35%和0.86 ns。两个模块在FOV中心的面内和正交面空间分辨率分别为1.9和4.4 mm。
Organ-dedicated PET scanners are becoming more prevalent because of their advantages in higher sensitivity, improved image quality, and lower cost. Detectors utilized in these scanners have finer pixel size with depth of interaction (DOI) capability. This work presents a LYSO(Ce) detector module with DOI capability which has the potential to be scaled up to a high-resolution small animal or organ-dedicated PET system. For DOI capability, a submodule with one LYSO block detector utilizing PETsys TOFPET2 application-specific integrated circuit (ASIC) was previously developed in our lab. We scaled up the submodule and optimized the configuration to allow for a compact housing of the dual-readout boards in one side of the blocks by designing a high-speed dual-readout cable to maintain the original pin-to-pin relationship between the Samtec connectors. The module size is 53.8 × 57.8 mm2. Each module has 2 × 2 LYSO blocks, each LYSO block consists of 4 × 4 LYSO units, and each LYSO unit contains a 6 × 6 array of 1 × 1 × 20 mm3 LYSO crystals. The four lateral surfaces of LYSO crystal were mechanically ground to W14, and the two end surfaces were polished. Two ends of the LYSO crystal are optically connected to SiPM for DOI measurement. Eight LYSO blocks performance including energy, timing, and DOI resolution is characterized with a single LYSO slab. The in-panel and orthogonal-panel spatial resolution of the two modules with 107.4 mm distance between each other are measured at 9 positions within the field of view (FOV) with a 22Na source. Results show that the average energy, timing, and DOI resolution of all LYSO blocks are 16.13% ± 1.01% at 511 keV, 658.03 ± 15.18 ps, and 2.62 ± 0.06 mm, respectively. The energy and timing resolution of two modules are 16.35% and 0.86 ns, respectively. The in-panel and orthogonal-panel spatial resolution of the two modules at the FOV center are 1.9 and 4.4 mm respectively.
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影响因子：
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