Exosomes: Emerging Cell-Free Based Therapeutics in Dermatologic Diseases.
Exosomes: Emerging Cell-Free Based Therapeutics in Dermatologic Diseases.
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DOI：
10.3389/fcell.2021.736022
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发表时间：
2021
影响因子：
5.5
通讯作者：
Qian H
中科院分区：
文献类型：
--
作者：
Shi H;Wang M;Sun Y;Yang D;Xu W;Qian H
Exosome是由多种细胞类型释放的脂双层囊泡。这些具有生物活性的囊泡正逐渐成为参与多种病理生理过程的细胞间通讯的领军人物。外切体能运输特定的、具有生物活性的运输货物，包括能够反映其母细胞的脂类、核酸和蛋白质，使其在无细胞疗法中具有吸引力。大量的研究结果证实了外切体在抑制瘢痕、烧伤、衰老和伤口愈合方面的关键作用。此外，在前沿研究中，外切体的生物学研究正在兴起，这使得制定特定的指南和质量控制方法成为可能，这有利于它们在未来的可能应用。本文就外切体在皮肤病的不同相关模式中的治疗潜力及其分子机制作一综述。此外，鉴于外切体具有良好的生物相容性和运输能力，还涉及到外切体的生物工程修饰。
Exosomes are lipid bilayer vesicles released by multiple cell types. These bioactive vesicles are gradually becoming a leading star in intercellular communication involving in various pathological and physiological process. Exosomes convey specific and bioactive transporting cargos, including lipids, nucleic acids and proteins which can be reflective of their parent cells, rendering them attractive in cell-free therapeutics. Numerous findings have confirmed the crucial role of exosomes in restraining scars, burning, senescence and wound recovery. Moreover, the biology research of exosomes in cutting-edge studies are emerging, allowing for the development of particular guidelines and quality control methodology, which favor their possible application in the future. In this review, we discussed therapeutic potential of exosomes in different relevant mode of dermatologic diseases, as well as the various molecular mechanisms. Furthermore, given the advantages of favorable biocompatibility and transporting capacity, the bioengineering modification of exosomes is also involved.
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