Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder
Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder
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重度抑郁症患者的受害者敏感性及其神经相关性
DOI：
10.3389/fpsyt.2020.00622
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发表时间：
2020-08
影响因子：
4.7
通讯作者：
Zhou Yuan
中科院分区：
文献类型：
--
作者：
Wang Xiaoming;Cui Shaojuan;Wu Michael Shengtao;Wang Yun;Gao Qinglin;Zhou Yuan
关于自我的不正常信念在抑郁症状的发展中很常见，但抑郁症患者对不公平待遇的反应，无论是性格上还是神经上，都尚不清楚。本研究旨在探讨重度抑郁障碍（MDD）患者与健康对照者作为受害者对不公正的敏感性及其神经相关因素的差异。方法首先选取发作性重度抑郁症drug-naïve患者（n = 30）和对照组（n = 30），比较两组患者受害者敏感性的差异。第二组MDD患者（n = 23）和对照组（n = 28）被招募来重复研究结果，并完成静息状态功能磁共振成像（fMRI）扫描。通过低频波动分数幅度（fALFF）测量的自发脑活动用于表征患者和健康对照中受害者敏感性的神经相关性。结果在两个数据集中，重度抑郁症患者的受害者敏感性均高于健康对照组。fALFF的多元回归分析显示，右侧背外侧前额叶皮层（DLPFC）的诊断与受害者敏感性之间存在显著的交互作用。结论重度抑郁症患者作为受害者对不公正表现出较高的敏感性，这可能与病程无关。重度抑郁症患者与健康对照者在受害者敏感性的神经相关方面存在差异。这些发现揭示了由DLPFC提供的认知控制与抑郁症患者中较高的受害者敏感性所牵连的自我负性偏见之间的联系。
Background Dysfunctional beliefs about the self are common in the development of depressive symptoms, but it remains unclear how depressed patients respond to unfair treatment, both dispositionally and neurally. The present research is an attempt to explore the differences in sensitivity to injustice as a victim and its neural correlates in patients with major depressive disorder (MDD) versus healthy controls. Methods First episodic, drug-naïve patients with MDD (n = 30) and a control group (n = 30) were recruited to compare their differences in victim sensitivity. A second group of patients with MDD (n = 23) and their controls (n = 28) were recruited to replicate the findings and completed resting-state functional magnetic resonance imaging (fMRI) scanning. Spontaneous brain activity measured by fractional amplitude of low-frequency fluctuation (fALFF) was used to characterize the neural correlates of victim sensitivity both in patients and in healthy controls. Results Higher victim sensitivity was consistently found in patients with MDD than healthy controls in both datasets. Multiple regression analysis on the fALFF showed a significant interaction effect between diagnosis and victim sensitivity in the right dorsolateral prefrontal cortex (DLPFC). Conclusions The patients with MDD show higher sensitivity to injustice as a victim, which may be independent of their disease course. The MDD patients differ from healthy controls in the neural correlates of victim sensitivity. These findings shed light on the linkage between cognitive control subserved by the DLPFC and negative bias towards the self implicated by higher victim sensitivity among the depressed patients.
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作者：
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发表时间：
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期刊：
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影响因子：
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DOI：
10.1093/cercor/bhw157
发表时间：
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期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
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