Cortical connections to area TE in monkey: hybrid modular and distributed organization.
Cortical connections to area TE in monkey: hybrid modular and distributed organization.
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DOI：
10.1093/cercor/bhp096
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Rockland KS
中科院分区：
文献类型：
--
作者：
Borra E;Ichinohe N;Sato T;Tanifuji M;Rockland KS
为了研究视觉关联区TE的皮质输入的精细解剖组织，在猕猴中进行2-3次逆行示踪剂的小注射。在光学成像和电生理记录后，作为终末程序进行注射，并靶向生理学上确定为对象选择性的贴片。逆行标记的神经元出现在几个单一模式视觉区域，即颞上沟、顶内沟（IPS）和前额叶皮质（PFC），这与之前的研究一致。上级颞沟、顶内沟（IPS）和前额叶皮质（PFC）。尽管注射尺寸小（<0.5 mm宽），但视觉区域中的投射灶（而不是IPS或PFC中的投射灶）在空间上分布广泛（范围为4-6 mm），并且主要由仅由一种注射标记的神经元组成。这可以被看作是一个准模块化的组织。此外，在每个投射焦点内，有分散的神经元投射到其他注射之一，以及一些双标记（DL）神经元，以更分散的模式。最后，投影焦点包括较小的“热点”，由混合的神经元组成，由不同的注射单标记，和DL神经元。DL神经元可能是轴突具有延伸的、空间上分离的终末乔木的结果，如顺行实验所示。这些结果表明，一个复杂的，混合连接架构，模块化和分布式组件。
To investigate the fine anatomical organization of cortical inputs to visual association area TE, 2–3 small injections of retrograde tracers were made in macaque monkeys. Injections were made as a terminal procedure, after optical imaging and electrophysiological recording, and targeted to patches physiologically identified as object-selective. Retrogradely labeled neurons occurred in several unimodal visual areas, the superior temporal sulcus, intraparietal sulcus (IPS), and prefrontal cortex (PFC), consistent with previous studies. Despite the small injection size (<0.5 mm wide), the projection foci in visual areas, but not in IPS or PFC, were spatially widespread (4–6 mm in extent), and predominantly consisted of neurons labeled by only one of the injections. This can be seen as a quasi-modular organization. In addition, within each projection focus, there were scattered neurons projecting to one of the other injections, together with some double-labeled (DL) neurons, in a more distributed pattern. Finally, projection foci included smaller “hotspots,” consisting of intermixed neurons, single-labeled by the different injections, and DL neurons. DL neurons are likely the result of axons having extended, spatially separated terminal arbors, as demonstrated by anterograde experiments. These results suggest a complex, hybrid connectivity architecture, with both modular and distributed components.
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影响因子：
2.5
作者：
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通讯作者：
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2.5
作者：
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通讯作者：
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