Aging membranes: Unexplored functions for lipids in the lifespan of the central nervous system.
Aging membranes: Unexplored functions for lipids in the lifespan of the central nervous system.
复制标题
DOI：
10.1016/j.exger.2019.110817
复制
发表时间：
2020-03
影响因子：
3.9
通讯作者：
Budin I
中科院分区：
文献类型：
--
作者：
Skowronska-Krawczyk D;Budin I
脂类构成了一组重要的生物代谢物，也是所有细胞膜的组成部分。众所周知，不同类脂物种的丰度和化学计量因寿命和代谢状态的不同而不同，但这些变化的功能影响一直难以理解。在这里，我们回顾了潜在的强大的交叉脂代谢，它决定了膜的组成和老化。我们首先介绍几个与衰老和衰老相关疾病相关的关键类脂，它们在生物体中被发现，以及它们如何作用于膜结构和功能。中性脂在能量储存和动态平衡中起主要作用，而不是中性脂，我们回顾了控制细胞膜物理化学性质的极性脂的已知功能。然后我们将重点放在中枢神经系统(CNS)的衰老过程中，中枢神经系统富含脂质，功能高度依赖于膜结构。最近的研究表明，脂质不仅是衰老和中枢神经系统相关变化的生物标记物，而且是这些过程的直接中介。作为一个模型系统，我们探索了视网膜中的脂肪酸组成如何影响衰老和衰老相关疾病。我们认为，膜结构对真核生物的基本过程--线粒体呼吸和自噬--的生物物理效应提供了脂质失调加速衰老过程的途径。最后，我们列出了增加对脂膜生物学的了解可以应用于衰老和寿命研究的方法。
Lipids constitute a significant group of biological metabolites and the building blocks of all cell membranes. The abundance and stoichiometries of different lipid species are known to vary across the lifespan and metabolic state, yet the functional effects of these changes have been challenging to understand. Here we review the potentially powerful intersection of lipid metabolism, which determines membrane composition and aging. We first introduce several key lipid classes that are associated with aging and aging-related disease, where they are found in organisms, and how they act on membrane structure and function. Instead of neutral lipids, which have primary roles in energy storage and homeostasis, we review known functions for polar lipids that control the physicochemical properties of cell membranes. We then focus on aging processes in the central nervous system (CNS), which is enriched in lipids and is highly dependent on membrane structure for function. Recent studies that show how lipids act not just as biomarkers of aging and associated changes in the CNS, but as direct mediators of these processes. As a model system, we explore how fatty acid composition in the retina impact aging and aging-related disease. We propose that the biophysical effects of membrane structure on fundamental eukaryotic processes - mitochondrial respiration and autophagy - provide avenues by which lipid dysregulation can accelerate aging processes. Finally, we lay out ways in which an increased understanding of lipid membrane biology can be applied to studies of aging and lifespan.
登录
查看更多内容
影响因子：
10.6
作者：
Bazan NG
通讯作者：
Bazan NG
DOI：
10.1016/j.plefa.2009.05.015
发表时间：
2009-08
期刊：
Prostaglandins, leukotrienes, and essential fatty acids
影响因子：
--
作者：
Cole GM;Ma QL;Frautschy SA
通讯作者：
Frautschy SA
DOI：
10.1136/bjophthalmol-2011-300344
发表时间：
2011-12
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Curcio CA;Johnson M;Rudolf M;Huang JD
通讯作者：
Huang JD
影响因子：
3.4
作者：
Albert, AD;Young, JE;Paw, Z
通讯作者：
Paw, Z
影响因子：
7.4
作者：
Cadenas, E;Davies, KJA
通讯作者：
Davies, KJA