Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure.
Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure.
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DOI：
10.1038/s41467-021-21574-w
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发表时间：
2021-03-04
影响因子：
16.6
通讯作者：
Kronenberg M
中科院分区：
文献类型：
--
作者：
Murray MP;Engel I;Seumois G;Herrera-De la Mata S;Rosales SL;Sethi A;Logandha Ramamoorthy Premlal A;Seo GY;Greenbaum J;Vijayanand P;Scott-Browne JP;Kronenberg M
Invariant natural killer T cells (iNKT cells) differentiate into thymic and peripheral NKT1, NKT2 and NKT17 subsets. Here we use RNA-seq and ATAC-seq analyses and show iNKT subsets are similar, regardless of tissue location. Lung iNKT cell subsets possess the most distinct location-specific features, shared with other innate lymphocytes in the lung, possibly consistent with increased activation. Following antigenic stimulation, iNKT cells undergo chromatin and transcriptional changes delineating two populations: one similar to follicular helper T cells and the other NK or effector like. Phenotypic analysis indicates these changes are observed long-term, suggesting that iNKT cells gene programs are not fixed, but they are capable of chromatin remodeling after antigen to give rise to additional subsets. Invariant natural killer T cells are known to be composed of a number of phenotypic and functionally distinct populations. Here the authors use transcriptomic and epigenomic analysis to further characterize the peripheral iNKT compartment before and after antigenic stimulation.
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影响因子：
16.6
作者：
Georgiev, Hristo;Ravens, Inga;Benarafa, Charaf;Foerster, Reinhold;Bernhardt, Guenter
通讯作者：
Bernhardt, Guenter
DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
5.4
作者：
Halder, Ramesh Chandra;Tran, Cynthia;Singh, Ram Raj
通讯作者：
Singh, Ram Raj
影响因子：
64.5
作者：
Lavin Y;Winter D;Blecher-Gonen R;David E;Keren-Shaul H;Merad M;Jung S;Amit I
通讯作者：
Amit I