Microbial Biomarkers of Intestinal Barrier Maturation in Preterm Infants.
Microbial Biomarkers of Intestinal Barrier Maturation in Preterm Infants.
复制标题
早产儿肠屏障成熟的微生物生物标志物。
DOI：
10.3389/fmicb.2018.02755
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发表时间：
2018
影响因子：
5.2
通讯作者：
Viscardi RM
中科院分区：
文献类型：
--
作者：
Ma B;McComb E;Gajer P;Yang H;Humphrys M;Okogbule-Wonodi AC;Fasano A;Ravel J;Viscardi RM
肠屏障不成熟，或“漏肠”，是早产婴儿易感坏死性小肠结肠炎的直接原因。然而，肠道微生物群发育对肠道黏膜屏障成熟的影响尚未在该人群中进行评估。在这项研究中，我们对38名妊娠< 33周的早产儿进行了纵向抽样，在出生后的前两周监测肠道通透性（IP）和粪便微生物群。肠道屏障功能成熟的IP快速下降与群落多样性显著增加相关。特别是梭状芽孢杆菌和双歧杆菌的成员具有高度的转录活性，梭状芽孢杆菌的丰度逐渐增加与肠道通透性降低显著相关。此外，先前确定的促进肠道屏障成熟的新生儿因素，包括早期纯母乳喂养和较短的抗生素暴露时间，与梭状芽孢杆菌在肠道微生物群中的早期定植有关，这些因素共同与早产儿肠道屏障功能的改善有关。
Intestinal barrier immaturity, or “leaky gut,” is the proximate cause of susceptibility to necrotizing enterocolitis in preterm neonates. However, the impact of intestinal microbiota development on intestinal mucosal barrier maturation has not been evaluated in this population. In this study, we investigated a longitudinally sampled cohort of 38 preterm infants < 33 weeks gestation monitored for intestinal permeability (IP) and fecal microbiota during the first 2 weeks of life. Rapid decrease in IP indicating intestinal barrier function maturation correlated with significant increase in community diversity. In particular, members of the Clostridiales and Bifidobacterium were highly transcriptionally active, and progressively increasing abundance in Clostridiales was significantly associated with decreased intestinal permeability. Further, neonatal factors previously identified to promote intestinal barrier maturation, including early exclusive breastmilk feeding and shorter duration antibiotic exposure, associate with the early colonization of the intestinal microbiota by members of the Clostridiales, which altogether are associated with improved intestinal barrier function in preterm infants.
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影响因子：
5.9
作者：
Cenit MC;Olivares M;Codoñer-Franch P;Sanz Y
通讯作者：
Sanz Y
影响因子：
7.3
作者：
Arrieta MC;Stiemsma LT;Amenyogbe N;Brown EM;Finlay B
通讯作者：
Finlay B
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
15.5
作者：
Fadrosh DW;Ma B;Gajer P;Sengamalay N;Ott S;Brotman RM;Ravel J
通讯作者：
Ravel J
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett