Myeloperoxidase-dependent LDL modifications in bloodstream are mainly predicted by angiotensin II, adiponectin, and myeloperoxidase activity: a cross-sectional study in men.
Myeloperoxidase-dependent LDL modifications in bloodstream are mainly predicted by angiotensin II, adiponectin, and myeloperoxidase activity: a cross-sectional study in men.
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DOI：
10.1155/2013/750742
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发表时间：
2013
影响因子：
4.6
通讯作者：
Roumeguère T
中科院分区：
文献类型：
--
作者：
Boudjeltia KZ;Delporte C;Van Antwerpen P;Franck T;Serteyn D;Moguilevsky N;Raes M;Vanhamme L;Vanhaeverbeek M;Van Meerhaeghe A;Roumeguère T
目前的动脉粥样硬化形成的范例提出，低密度脂蛋白（LDL）被困在血管壁的内皮下空间，在那里它们被氧化。以前，我们表明，氧化并不局限于内皮下的位置。髓过氧化物酶（MPO）是由中性粒细胞和巨噬细胞分泌的一种酶，可修饰内皮细胞表面的低密度脂蛋白（Mox-LDL）。此外，我们观察到血管紧张素II对内皮细胞的激活放大了这一过程。我们认为NADPH氧化酶复合物的诱导是氧化过程中的主要步骤。基于这些数据，我们在121例患者中询问NADPH氧化酶调节剂（如血管紧张素II、脂联素）与循环Mox-LDL水平之间是否存在独立关联。我们的观察结果表明，血液血管紧张素II，MPO活性和脂联素的组合解释，至少部分，血清Mox-LDL水平。
The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO), an enzyme secreted by neutrophils and macrophages, can modify LDL (Mox-LDL) at the surface of endothelial cells. In addition we observed that the activation of the endothelial cells by angiotensin II amplifies this process. We suggested that induction of the NADPH oxidase complex was a major step in the oxidative process. Based on these data, we asked whether there was an independent association, in 121 patients, between NADPH oxidase modulators, such as angiotensin II, adiponectin, and levels of circulating Mox-LDL. Our observations suggest that the combination of blood angiotensin II, MPO activity, and adiponectin explains, at least partially, serum Mox-LDL levels.
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影响因子：
3.7
作者：
Boudjeltia, Karim Zouaoui;Faraut, Brice;Kerkhofs, Myriam
通讯作者：
Kerkhofs, Myriam
影响因子：
3.1
作者：
Li, Hong;Cao, Zehong;Cheng, Guangjie
通讯作者：
Cheng, Guangjie
DOI：
10.1016/j.bbrc.2004.10.049
发表时间：
2004-12-10
影响因子：
3.1
作者：
Boudjeltia, KZ;Moguilevsky, N;Remacle, C
通讯作者：
Remacle, C
影响因子：
6.1
作者：
Delporte, Cedric;Franck, Thierry;Boudjeltia, Karim Zouaoui
通讯作者：
Boudjeltia, Karim Zouaoui
影响因子：
6.1
作者：
Franck, T.;Kohnen, S.;Serteyn, D.
通讯作者：
Serteyn, D.