Rheumatoid arthritis and cardiovascular disease.

Rheumatoid arthritis and cardiovascular disease.
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类风湿关节炎和心血管疾病。

DOI:
10.1016/j.ahj.2013.07.010
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发表时间:
2013-10
影响因子:
4.8
通讯作者:
Gabriel, Sherine E.
Gabriel, Sherine E.
中科院分区:
医学2区
文献类型:
--
作者:
Crowson, Cynthia S.;Liao, Katherine P.;Davis, John M., III;Solomon, Daniel H.;Matteson, Eric L.;Knutson, Keith L.;Hlatky, Mark A.;Gabriel, Sherine E.

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风湿病和心脏病有共同的基础,涉及炎症。以风湿性疾病为特征的高水平炎症为阐明炎症加速心脏病的机制提供了一个“自然的实验”。类风湿性关节炎(RA)是风湿性疾病中最常见的一种,也是研究最多的与心脏病的关系。回顾目前有关心脏病和类风湿性关节炎的文献,患有类风湿关节炎的患者发生心脏病的风险增加,而传统的心血管危险因素无法完全解释这种风险。用于治疗类风湿性关节炎的疗法也可能影响心脏病的发展;通过抑制炎症,它们也可能降低心脏病的风险。然而,它们的其他作用,如类固醇,可能会增加心脏病的风险。对RA先天和获得性免疫反应的研究有助于阐明心脏病发病机制中的新机制,并有助于确定心脏病预防和治疗的新靶点。
Rheumatic disease and heart disease share common underpinnings involving inflammation. The high levels of inflammation that characterize rheumatic diseases provide a “natural experiment” to help elucidate the mechanisms by which inflammation accelerates heart disease. Rheumatoid arthritis (RA) is the most common of the rheumatic diseases and has the best studied relationships with heart disease. Review of current literature on heart disease and rheumatoid arthritis Patients with RA have an increased risk of developing heart disease that is not fully explained by traditional cardiovascular risk factors. Therapies used to treat RA may also affect the development of heart disease; by suppressing inflammation, they may also reduce the risk of heart disease. However, their other effects, as in the case of steroids, may increase heart disease risk. Investigations of the innate and adaptive immune responses occurring in RA may delineate novel mechanisms in the pathogenesis of heart disease, and help identify novel therapeutic targets for the prevention and treatment of heart disease.
动脉粥样硬化性脂质谱是早期类风湿关节炎患者的特征特征:早期治疗的作用 - 一项前瞻性,对照研究。
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