Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection.
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection.
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DOI：
10.1038/s41590-021-01028-7
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发表时间：
2021-11
影响因子：
30.5
通讯作者：
Di Santo JP
中科院分区：
文献类型：
--
作者：
Smith N;Goncalves P;Charbit B;Grzelak L;Beretta M;Planchais C;Bruel T;Rouilly V;Bondet V;Hadjadj J;Yatim N;Pere H;Merkling SH;Ghozlane A;Kernéis S;Rieux-Laucat F;Terrier B;Schwartz O;Mouquet H;Duffy D;Di Santo JP
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染后协调的局部粘膜和系统免疫反应要么预防冠状病毒病2019(新冠肺炎)病理，要么失败，导致严重的临床后果。为了了解这一过程，我们对急性感染期间临床不同的新冠肺炎患者的鼻咽拭子和血浆样本中的SARS-CoV-2刺突特异性抗体、细胞因子、病毒载量和细菌群落进行了综合分析。血浆病毒载量与全身炎症细胞因子在重症新冠肺炎患者中升高有关，也与刺激性中和抗体有关。相比之下，鼻咽病毒载量与SARS-CoV-2体液反应相关，但与干扰素反应相反，后者与保护性微生物群落相关。潜在的病原微生物，通常与继发性呼吸道感染有关，与黏膜炎症有关，在严重的新冠肺炎中升高。我们的结果显示了SARS-CoV-2免疫反应的不同组织区划，并强调了鼻咽微生物群在调节局部和系统免疫中的作用，这决定了新冠肺炎的临床结果。呼吸道粘膜表面是SARS-CoV-2进入和防御的第一个部位。Di Santo和他的同事对感染SARS-CoV-2的患者的鼻咽和全身免疫反应进行了配对分析，并展示了明显的免疫分区和微生物组的变化。
Coordinated local mucosal and systemic immune responses following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either protect against coronavirus disease 2019 (COVID-19) pathologies or fail, leading to severe clinical outcomes. To understand this process, we performed an integrated analysis of SARS-CoV-2 spike-specific antibodies, cytokines, viral load and bacterial communities in paired nasopharyngeal swabs and plasma samples from a cohort of clinically distinct patients with COVID-19 during acute infection. Plasma viral load was associated with systemic inflammatory cytokines that were elevated in severe COVID-19, and also with spike-specific neutralizing antibodies. By contrast, nasopharyngeal viral load correlated with SARS-CoV-2 humoral responses but inversely with interferon responses, the latter associating with protective microbial communities. Potential pathogenic microorganisms, often implicated in secondary respiratory infections, were associated with mucosal inflammation and elevated in severe COVID-19. Our results demonstrate distinct tissue compartmentalization of SARS-CoV-2 immune responses and highlight a role for the nasopharyngeal microbiome in regulating local and systemic immunity that determines COVID-19 clinical outcomes. Mucosal surfaces of the respiratory tract are the first sites of entry and defense against SARS-CoV-2. Di Santo and colleagues perform paired analysis of the nasopharyngeal and systemic immune responses of SARS-CoV-2-infected patients and demonstrate distinct compartmentalization of immunity and shifts in the microbiome.
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影响因子：
14.2
作者：
Lan, Feng;Zhong, Hua;Bachert, Claus
通讯作者：
Bachert, Claus
危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
24.8
作者：
Isho B;Abe KT;Zuo M;Jamal AJ;Rathod B;Wang JH;Li Z;Chao G;Rojas OL;Bang YM;Pu A;Christie-Holmes N;Gervais C;Ceccarelli D;Samavarchi-Tehrani P;Guvenc F;Budylowski P;Li A;Paterson A;Yue FY;Marin LM;Caldwell L;Wrana JL;Colwill K;Sicheri F;Mubareka S;Gray-Owen SD;Drews SJ;Siqueira WL;Barrios-Rodiles M;Ostrowski M;Rini JM;Durocher Y;McGeer AJ;Gommerman JL;Gingras AC
通讯作者：
Gingras AC