Neuroimmunological findings in allergic skin diseases
Neuroimmunological findings in allergic skin diseases
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过敏性皮肤病的神经免疫学研究结果
DOI：
--
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发表时间：
2005
影响因子：
2.8
通讯作者：
A. Kapp
中科院分区：
文献类型：
--
作者：
U. Raap;A. Kapp
综述目的最近的研究已经获得了关于遗传、环境、免疫学和药理学因素的复杂调控的广泛信息，这些因素有助于变态反应性炎症性皮肤病的发展，如特应性皮炎。然而，神经免疫机制仍有待阐明。本文将重点介绍特应性皮炎等过敏性炎症性皮肤中皮肤免疫与周围神经系统的相互作用。特应性皮炎皮损中神经肽和神经肽阳性神经纤维显著增多。周围神经末梢处于兴奋状态时，神经纤维密度增加。在这方面，神经营养因子对神经细胞的功能作用被特别描述，在特应性皮炎皮肤中也有表达。此外，神经营养因子调节嗜酸性粒细胞作为特应性皮炎主要靶效应细胞的功能，正如最近所描述的那样。有趣的是，嗜酸性粒细胞能够产生神经营养因子和神经肽本身，这表明神经元细胞群和主要靶标效应细胞之间存在双向通讯。神经营养因子和神经肽对感觉神经元和免疫细胞的功能活动均有调节作用。因此，我们提出了靶效应细胞和感觉神经之间的神经免疫网络的概念，将致病事件与变态反应性炎症性皮肤病的皮肤免疫和周围神经系统功能障碍联系起来。
Purpose of reviewRecent studies have gained widespread information about the complex regulation of genetic, environmental, immunologic, and pharmacologic factors that contribute to the development of allergic inflammatory skin diseases such as atopic dermatitis. Neuroimmune mechanisms, however, still remain to be elucidated. This review will focus on the interaction between the cutaneous immune and peripheral nervous system in allergic inflammatory skin such as atopic dermatitis. Recent findingsNeuropeptides and neuropeptide-positive nerve fibres are prominently increased in lesions of atopic dermatitis. The density of nerve fibres is increased while peripheral nerve endings are in an active state of excitation. In this regard, neurotrophins particularly described for their functional role on nerve cells are also expressed in atopic dermatitis skin. In addition, neurotrophins modulate the functional role of eosinophils as main target effector cells in atopic dermatitis, as described recently. Interestingly, eosinophils are capable of neurotrophin as well as neuropeptide production itself, pointing to a bidirectional communication between neuronal cell populations and main target effector cells. SummaryNeurotrophins and neuropeptides modulate both the functional activity of sensory neurons and immune cells. We have therefore developed the concept of a neuroimmune network between target effector cells and sensory nerves that links pathogenic events to dysfunctions of the cutaneous immune and peripheral nervous system in allergic inflammatory skin diseases.
trk 受体家族介导黑素细胞中神经生长因子和神经营养素 3 的作用。
DOI：
10.1172/jci117496
发表时间：
1994
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Yaar,M;Eller,MS;DiBenedetto,P;Reenstra,WR;Zhai,S;McQuaid,T;Archambault,M;Gilchrest,BA
通讯作者：
Gilchrest,BA
DOI：
10.1016/s0006-291x(87)80293-0
发表时间：
1987-11-13
影响因子：
3.1
作者：
ALIAKBARI, J;SREEDHARAN, SP;GOETZL, EJ
通讯作者：
GOETZL, EJ