Contrasting epidemiology and genetic variation of Plasmodium vivax infecting Duffy-negative individuals across Africa.
Contrasting epidemiology and genetic variation of Plasmodium vivax infecting Duffy-negative individuals across Africa.
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DOI：
10.1016/j.ijid.2021.05.009
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发表时间：
2021-07
影响因子：
8.4
通讯作者：
Paganotti, Giacomo Maria
中科院分区：
文献类型：
--
作者：
Lo, Eugenia;Russo, Gianluca;Pestana, Kareen;Kepple, Daniel;Abagero, Beka Raya;Dongho, Ghyslaine Bruna Djeunang;Gunalan, Karthigayan;Miller, Louis H.;Hamid, Muzamil Mahdi Abdel;Yewhalaw, Delenasaw;Paganotti, Giacomo Maria
关键词：
间日疟原虫疟疾被认为是罕见的非洲人谁缺乏达菲血型抗原表达。然而，最近的研究表明，间日疟原虫可以感染达菲阴性个体，并已渗透到非洲达菲阴性率高的地区。本研究比较了非洲地区间日疟原虫的流行病学和遗传学特征。我们利用标准化方法鉴定和量化来自博茨瓦纳、埃塞俄比亚和苏丹的间日疟原虫，在这些地区达菲阳性和达菲阴性个体共存。对非洲间日疟原虫的Duffy Binding Protein（DBP）基因进行了序列测定，并初步推断了非洲间日疟原虫的亲缘关系。在1,215名发热患者中，达菲阴性的比例从东非的20-36%到南部非洲的84%不等。达菲阴性人群中间日疟原虫的患病率从苏丹的平均9.2%到博茨瓦纳的86%不等。Duffy阴性的寄生虫密度显著低于Duffy阳性感染。Duffy阴性群体中的间日疟原虫不是单系的。Duffy阴性和Duffy阳性间日疟原虫具有相似的DBP单倍型，并出现在多个支持良好的分支中。Duffy阴性的非洲人对间日疟原虫不耐药，其公共卫生意义不容忽视。这项研究强调需要标准化的方法和更多的资源/培训，以诊断非洲的间日疟。
Plasmodium vivax malaria was thought to be rare in Africans who lack the Duffy blood group antigen expression. However, recent studies indicate that P. vivax can infect Duffy-negative individuals and has penetrated into areas of high Duffy-negativity across Africa. This study compares epidemiological and genetic features of P. vivax between African regions. We utilized a standardized approach to identify and quantify P. vivax from Botswana, Ethiopia, and Sudan, where Duffy-positive and Duffy-negative individuals coexist. We sequenced Duffy Binding Protein (DBP) gene and inferred genetic relationships among all Africa P. vivax. Among 1,215 febrile patients, the proportions of Duffy negativity range from 20–36% in East Africa to 84% in Southern Africa. P. vivax prevalence among Duffy-negative populations ranging from averaged 9.2% in Sudan to 86% in Botswana. Parasite density in Duffy-negative is significantly lower than in Duffy-positive infections. P. vivax in Duffy-negative populations were not monophyletic. Duffy-negative and Duffy-positive P. vivax shared similar DBP haplotypes and occurred in multiple well-supported clades. Duffy-negative Africans are not resistant to P. vivax and the public health significance should not be neglected. This study highlights need for standardized approach and more resources/training to diagnosis of vivax malaria in Africa.
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DOI：
10.1073/pnas.1810053115
发表时间：
2018-09-04
影响因子：
11.1
作者：
Loy DE;Plenderleith LJ;Sundararaman SA;Liu W;Gruszczyk J;Chen YJ;Trimboli S;Learn GH;MacLean OA;Morgan ALK;Li Y;Avitto AN;Giles J;Calvignac-Spencer S;Sachse A;Leendertz FH;Speede S;Ayouba A;Peeters M;Rayner JC;Tham WH;Sharp PM;Hahn BH
通讯作者：
Hahn BH
DOI：
10.1073/pnas.1818485116
发表时间：
2019-04-02
影响因子：
11.1
作者：
Gunalan, Karthigayan;Sa, Juliana M.;Miller, Louis H.
通讯作者：
Miller, Louis H.
影响因子：
7.7
作者：
Busby, George B. J.;Band, Gavin;Spencer, Chris C. A.
通讯作者：
Spencer, Chris C. A.
影响因子：
3.3
作者：
Brazeau, Nicholas F.;Whitesell, Amy N.;Meshnick, Steven R.
通讯作者：
Meshnick, Steven R.
影响因子：
4.5
作者：
Hollfelder N;Schlebusch CM;Günther T;Babiker H;Hassan HY;Jakobsson M
通讯作者：
Jakobsson M