Target-derived astroglia regulate axonal outgrowth in a region-specific manner.
Target-derived astroglia regulate axonal outgrowth in a region-specific manner.
复制标题
靶源性星形胶质细胞以区域特异性方式调节轴突生长。
DOI：
10.1016/0012-1606(92)90284-n
复制
发表时间：
1992
影响因子：
2.7
通讯作者：
Levitt,P
中科院分区：
文献类型：
--
作者：
Qian,JA;Bull,MS;Levitt,P
使用体外共培养系统研究了星形胶质细胞对神经突生长的潜在神经解剖学特异性，其中来自胚胎大鼠脊髓或海马的神经元在来自大鼠中枢神经系统的同一区域（同位共培养）或不同区域（异位共培养）的星形胶质细胞存在但不直接接触的情况下生长4天。结果表明，在异位共培养中，轴突的生长大大增强，其中脊髓或海马神经元与来自适当中枢神经系统目标区域的星形胶质细胞一起生长。这种效应非常具体，因为从脊髓或海马目标区域收获的星形胶质细胞不能有效促进非传入神经元群的轴突生长。在所有共培养条件下，树突生长相似。这些数据表明，星形胶质细胞产生的扩散信号可以以神经解剖学特异性方式在体外调节神经突延伸，并且轴突比树突对区域星形胶质细胞环境更敏感。
The potential neuroanatomical specificity of astrocyte influence on neurite outgrowth was studied using anin vitrococulture system in which neurons from embryonic rat spinal cord or hippocampus were grown for 4 days in the presence of, but not in direct contact with, astrocytes derived either from the same region (homotopic coculture) or from different regions (heterotopic coculture) of the rat central nervous system. The results showed that axonal outgrowth was greatly enhanced in heterotopic cocultures in which spinal cord or hippocampal neurons were grown with astrocytes derived from their appropriate CNS target regions. This effect was remarkably specific, because the astroglia harvested from spinal or hippocampal target regions were not effective in promoting axon growth of nonafferent neuronal populations. Dendritic outgrowth was similar under all coculture conditions. These data suggest that diffusible signals, produced by astrocytes, can regulate neurite extensionin vitroin a neuroanatomically specific manner and that axons are more sensitive than dendrites to the regional astrocyte environment.
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分子和细胞生物学的细胞培养方法
影响因子：
17.3
作者：
M. C. Berenbaum
通讯作者：
M. C. Berenbaum
小鼠小脑星形胶质细胞在神经元存活和分化中发挥作用吗
DOI：
--
发表时间：
1987
期刊：
影响因子：
--
作者：
B. Pessac;F. Alliot
通讯作者：
F. Alliot
体外星形胶质细胞在 α1 肾上腺素能受体的表达方面存在异质性
影响因子：
6.2
作者：
L. Lerea;K. McCarthy
通讯作者：
K. McCarthy
影响因子：
6.6
作者：
G. Shaw;G. Banker;K. Weber
通讯作者：
G. Shaw;G. Banker;K. Weber
影响因子：
16.2
作者：
BRUCKENSTEIN, DA;LEIN, PJ;FREMEAU, RT
通讯作者：
FREMEAU, RT