Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease.
Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease.
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DOI：
10.3390/ijms17091379
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发表时间：
2016-08-23
影响因子：
5.6
通讯作者：
Ota T
中科院分区：
文献类型：
--
作者：
Chen G;Ni Y;Nagata N;Xu L;Ota T
非酒精性脂肪性肝病(NAFLD)是世界范围内最重要的慢性肝病之一，近几十年来受到越来越多的关注。非酒精性脂肪性肝病的特点是广泛的肝脏改变，从单纯性脂肪变性到非酒精性脂肪性肝炎、肝硬变和肝细胞癌。NAFLD的发病机制非常复杂，涉及脂肪堆积、胰岛素抵抗、炎症和纤维化。NAFLD与肥胖、糖尿病、脂肪性肝炎和肝纤维化等并发症密切相关。在NAFLD的发展过程中，活性氧物种(ROS)被激活并诱导氧化应激。最近建立有效的NAFLD治疗方法的尝试已经确定了潜在的微量营养素抗氧化剂，这些抗氧化剂可能减少ROS的积累，并最终改善疾病。本文综述了NAFLD发病的分子机制，并介绍了一些可用于预防或治疗NAFLD的膳食抗氧化剂，如维生素D、E和虾青素。
Nonalcoholic fatty liver disease (NAFLD) is one of the most important chronic liver diseases worldwide and has garnered increasing attention in recent decades. NAFLD is characterized by a wide range of liver changes, from simple steatosis to nonalcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. The blurred pathogenesis of NAFLD is very complicated and involves lipid accumulation, insulin resistance, inflammation, and fibrogenesis. NAFLD is closely associated with complications such as obesity, diabetes, steatohepatitis, and liver fibrosis. During the progression of NAFLD, reactive oxygen species (ROS) are activated and induce oxidative stress. Recent attempts at establishing effective NAFLD therapy have identified potential micronutrient antioxidants that may reduce the accumulation of ROS and finally ameliorate the disease. In this review, we present the molecular mechanisms involved in the pathogenesis of NAFLD and introduce some dietary antioxidants that may be used to prevent or cure NAFLD, such as vitamin D, E, and astaxanthin.
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影响因子：
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作者：
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