Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation.
Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation.
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作者：
Lee TW;Kwon H;Zong H;Yamada E;Vatish M;Pessin JE;Bastie CC
先前的研究已经证明，标准食物饮食的Fyn敲除（FynKO）小鼠显示出增加的葡萄糖清除率和全身胰岛素敏感性，这与由增加的脂肪酸使用和能量消耗引起的肥胖减少相关。然而，令人惊讶的是，尽管在高脂肪饮食中脂肪组织（AT）质量积累的程度相似，但FynKO小鼠仍然完全葡萄糖耐受和胰岛素敏感。生理学分析表明，FynKO小鼠具有以下组合：向皮下隔室而不是内脏贮库中偏斜的AT扩增，与减少的T细胞和巨噬细胞浸润相关的AT炎症减少，以及抗炎M2巨噬细胞比例增加。这些数据表明，Fyn是全身综合代谢的重要调节因子，在营养过剩状态下协调AT扩张、炎症和胰岛素敏感性。这些数据进一步表明，Fyn功能的抑制可能提供一个新的目标，以防止AT炎症，胰岛素抵抗和代谢综合征的血脂异常的组成部分。
Previous studies have demonstrated that Fyn knockout (FynKO) mice on a standard chow diet display increased glucose clearance and whole-body insulin sensitivity associated with decreased adiposity resulting from increased fatty acid use and energy expenditure. Surprisingly, however, despite a similar extent of adipose tissue (AT) mass accumulation on a high-fat diet, the FynKO mice remained fully glucose tolerant and insulin sensitive. Physiologic analyses demonstrated that the FynKO mice had a combination of skewed AT expansion into the subcutaneous compartment rather than to the visceral depot, reduced AT inflammation associated with reduced T-cell and macrophage infiltration, and increased proportion of anti-inflammatory M2 macrophages. These data demonstrate that Fyn is an important regulator of whole-body integrative metabolism that coordinates AT expansion, inflammation, and insulin sensitivity in states of nutrient excess. These data further suggest that inhibition of Fyn function may provide a novel target to prevent AT inflammation, insulin resistance, and the dyslipidemia components of the metabolic syndrome.
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影响因子：
7.7
作者：
Lumeng, Carey N.;DeYoung, Stephanie M.;Saltiel, Alan R.
通讯作者：
Saltiel, Alan R.
DOI：
10.4049/jimmunol.1100367
发表时间：
2011-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
MacIver NJ;Blagih J;Saucillo DC;Tonelli L;Griss T;Rathmell JC;Jones RG
通讯作者：
Jones RG
肿瘤坏死因子-α的脂肪表达--在与肥胖相关的胰岛素抵抗中的直接作用
影响因子：
56.9
作者：
HOTAMISLIGIL, GS;SHARGILL, NS;SPIEGELMAN, BM
通讯作者：
SPIEGELMAN, BM
DOI：
10.1046/j.1467-789x.2000.00008.x
发表时间：
2000-05-01
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Bosello, O;Zamboni, M
通讯作者：
Zamboni, M
影响因子：
4.8
作者：
Lee, JY;Sohn, KH;Hwang, D
通讯作者：
Hwang, D