The Obesity Paradox in Lung Cancer: Associations With Body Size Versus Body Shape.
The Obesity Paradox in Lung Cancer: Associations With Body Size Versus Body Shape.
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DOI：
10.3389/fonc.2020.591110
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发表时间：
2020
影响因子：
4.7
通讯作者：
Kiefte-de Jong JC
中科院分区：
文献类型：
--
作者：
Ardesch FH;Ruiter R;Mulder M;Lahousse L;Stricker BHC;Kiefte-de Jong JC
肥胖和肺癌（LC）之间的关系仍然知之甚少。然而，以体型而不是体型为基础的其他肥胖指标尚未得到研究。本研究的目的是评估体型和体型的不同指标与LC风险之间的关系。该研究特别研究了A型身材指数（Body Shape Index）与LC风险之间的关系。A型身材指数是一种比传统人体测量方法更精确的腹部脂肪指标。在鹿特丹研究的前瞻性队列中，我们分析了9689名参与者的数据。LC诊断基于医疗记录，并在基线评估人体测量值。采用相应风险比的cox -回归分析来检验人体测量值与LC风险之间的关系，并对潜在混杂因素进行调整。使用似然比（LR）检验，用三次样条探讨潜在的非线性关联。随访期间，319名参与者发展为LC。身体质量指数（BMI）与肺癌风险呈负相关（HR 0.94, 95% CI: 0.91-0.97），并且在排除肺癌病例后的前10年随访中仍然存在。有证据表明BMI与肺癌风险呈非线性相关（0,04,df = 1），这表明BMI与肺癌的负相关主要存在于非肥胖参与者中。腰围（WC） （HR 1.03 95% CI: 1.01-1.05）、腰臀比（HR 1.23 95% CI: 1.09-1.38）和ABSI （A体型指数）（HR 1.17 95% CI: 1.05-1.30）与肺癌的风险呈线性正相关。体型而不是体型可能是LC的重要风险指标。未来的研究应关注内脏脂肪的作用和LC的风险及其潜在机制。
The association between obesity and lung cancer (LC) remains poorly understood. However, other indices of obesity on the basis of body shape instead of body size have not been examined yet. The aim of this study was to evaluate the association between different indices of body size and body shape and the risk of LC. In particular, this study examined the association between A Body Shape Index, a more precise indicator of abdominal fat than traditional anthropometric measures, and the risk of LC. In the prospective cohort the Rotterdam Study, we analysed data of 9,689 participants. LC diagnoses were based on medical records and anthropometric measurements were assessed at baseline. Cox-regression analyses with corresponding Hazard Ratios were used to examine the association between the anthropometric measurements and the risk of LC with adjustment for potential confounders. Potential non-linear associations were explored with cubic splines using the Likelihood ratio (LR) test. During follow-up, 319 participants developed LC. Body mass Index (BMI) was inversely associated with the risk of lung cancer (HR 0.94, 95% CI: 0.91–0.97) and persisted after excluding lung cancer cases during the first 10 years of follow-up. There was evidence for a non-linear association between BMI and the risk of lung cancer (0,04, df = 1), which indicated that the inverse association between BMI and lung cancer was mainly present in non-obese participants. Waist circumference (WC) (HR 1.03 95% CI: 1.01–1.05), Waist-to-Hip Ratio (WHR) (HR 1.23 95% CI: 1.09–1.38) and ABSI (A Body Shape Index) (HR 1.17 95% CI: 1.05–1.30) were positively and linearly associated with the risk of lung cancer. Body shape rather than body size may be an important risk indicator of LC. Future research should focus on the role of visceral fat and the risk of LC as well as the underlying mechanisms.
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影响因子：
7.2
作者：
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通讯作者：
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影响因子：
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作者：
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期刊：
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影响因子：
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影响因子：
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作者：
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影响因子：
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