Sex similarities and differences in pain-related periaqueductal gray connectivity.
Sex similarities and differences in pain-related periaqueductal gray connectivity.
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DOI：
10.1016/j.pain.2011.11.006
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发表时间：
2012-02
期刊：
影响因子：
7.4
通讯作者：
Kong J
中科院分区：
文献类型：
--
作者：
Linnman C;Beucke JC;Jensen KB;Gollub RL;Kong J
这项研究调查了60名健康受试者在疼痛相关功能连接方面的性别相似性和差异性。我们使用功能磁共振成像和心理生理相互作用分析来研究低和高实验性疼痛暴露如何调节中脑导水管周围灰质(PAG)的功能连接。我们发现痛阈值没有性别差异，在男性和女性中，高度疼痛时，PAG与躯体感觉皮质、辅助运动区、小脑和丘脑的功能联系更多，这与解剖学预测一致。26名男性表现出疼痛诱导的PAG与杏仁核、尾状核和壳核的功能连接增加，这在女性中没有观察到。在广泛的文献搜索中，我们发现，当PAG和杏仁核之间的联系被描述时，女性动物在很大程度上被忽视了，而女性在内源性疼痛抑制方面被系统地研究不足。我们的结果强调了在研究疼痛处理的基本机制时包括男性和女性受试者的重要性，并指出在内源性疼痛抑制方面可能存在性别差异。
This study investigated sex similarities and differences in pain-related functional connectivity in 60 healthy subjects. We used functional magnetic resonance imaging and psychophysiological interaction analysis to investigate how exposure to low vs high experimental pain modulates the functional connectivity of the periaqueductal gray (PAG). We found no sex differences in pain thresholds, and in both men and women, the PAG was more functionally connected with the somatosensory cortex, the supplemental motor area, cerebellum, and thalamus during high pain, consistent with anatomic predictions. Twenty-six men displayed a pain-induced increase in PAG functional connectivity with the amygdala caudate and putamen that was not observed in women. In an extensive literature search, we found that female animals have been largely overlooked when the connections between the PAG and the amygdala have been described, and that women are systematically understudied with regard to endogenous pain inhibition. Our results emphasize the importance of including both male and female subjects when studying basic mechanisms of pain processing, and point toward a possible sex difference in endogenous pain inhibition.
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