Evidence for two genetic variants of Pneumocystis carinii coinfecting laboratory rats
Evidence for two genetic variants of Pneumocystis carinii coinfecting laboratory rats
复制标题
卡氏肺孢子虫共感染实验室大鼠的两种遗传变异的证据
DOI：
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发表时间：
1993
影响因子：
9.4
通讯作者：
James R. Stringer
中科院分区：
文献类型：
--
作者：
M. Cushion;Jianxiong Zhang;Michael Kaselis;David Giuntoli;S. Stringer;James R. Stringer
Pneumocystis carinii pneumonia is an oftentimes fatal infection for hosts in an immunocompromised state. The disease occurs in a wide variety of mammals, but the etiologic agent of this disease has been referred to as P. carinii regardless of the host species. However, even within a single host species, such as laboratory rats, distinct varieties of P. carinii have been identified from differences in the electrophoretic migration of chromosomes in agarose gels. Here we present evidence indicating that some laboratory rats can contain two different genetic variants of P. carinii that differ not only in electrophoretic karyotype but also in the presence of a particular repeated DNA sequence, in the presence of an intron in the 18S ribosomal RNA gene, and in the sequence of part of the 18S rRNA gene. Most of the rat colonies studied were infected with P. carinii that contained the repeated DNA and the 18S rRNA gene intron. The other type of rat-derived P. carinii, which lacked the repeated DNA and the intron in the 18S rRNA gene, was found as a coinfection with the first. Parasite populations from different coinfected rats contained the two variants in different proportions.
真菌的分子进化：人类病原体。
影响因子：
10.7
作者：
Bowman,BH;Taylor,JW;White,TJ
通讯作者：
White,TJ
大鼠肺、细胞培养物和雪貂肺的卡氏肺孢子虫脉冲场凝胶电泳核型比较。
DOI：
--
发表时间：
1991
期刊：
The Journal of protozoology
影响因子：
--
作者：
Weinberg,GA;Bartlett,MS
通讯作者：
Bartlett,MS
卡氏肺囊虫小亚基 rRNA 基因中的自剪接内含子。
影响因子：
14.9
作者：
Sogin,ML;Edman,JC
通讯作者：
Edman,JC