Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.
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DOI：
10.1038/ng.2390
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发表时间：
2012-10
期刊：
影响因子：
30.8
通讯作者：
Aung, Tin
中科院分区：
文献类型：
--
作者：
Vithana, Eranga N.;Khor, Chiea-Chuen;Qiao, Chunyan;Nongpiur, Monisha E.;George, Ronnie;Chen, Li-Jia;Tan Do;Abu-Amero, Khaled K.;Huang, Chor Kai;Low, Sancy;Tajudin, Liza-Sharmini A.;Perera, Shamira A.;Cheng, Ching-Yu;Xu, Liang;Jia, Hongyan;Ho, Ching-Lin;Sim, Kar Seng;Wu, Ren-Yi;Tham, Clement C. Y.;Chew, Paul T. K.;Su, Daniel H.;Oen, Francis T.;Sarangapani, Sripriya;Soumittra, Nagaswamy;Osman, Essam A.;Wong, Hon-Tym;Tang, Guangxian;Fan, Sujie;Meng, Hailin;Huong, Dao T. L.;Wang, Hua;Feng, Bo;Baskaran, Mani;Shantha, Balekudaru;Ramprasad, Vedam L.;Kumaramanickavel, Govindasamy;Iyengar, Sudha K.;How, Alicia C.;Lee, Kelvin Y.;Sivakumaran, Theru A.;Yong, Victor H. K.;Ting, Serena M. L.;Li, Yang;Wang, Ya-Xing;Tay, Wan-Ting;Sim, Xueling;Lavanya, Raghavan;Cornes, Belinda K.;Zheng, Ying-Feng;Wong, Tina T.;Loon, Seng-Chee;Yong, Vernon K. Y.;Waseem, Naushin;Yaakub, Azhany;Chia, Kee-Seng;Allingham, R. Rand;Hauser, Michael A.;Lam, Dennis S. C.;Hibberd, Martin L.;Bhattacharya, Shomi S.;Zhang, Mingzhi;Teo, Yik Ying;Tan, Donald T.;Jonas, Jost B.;Tai, E-Shyong;Saw, Seang-Mei;Do Nhu Hon;Al-Obeidan, Saleh A.;Liu, Jianjun;Tran Nguyen Bich Chau;Simmons, Cameron P.;Bei, Jin-Xin;Zeng, Yi-Xin;Foster, Paul J.;Vijaya, Lingam;Wong, Tien-Yin;Pang, Chi-Pui;Wang, Ningli;Aung, Tin
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10−12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10−10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10−9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.
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影响因子：
30.8
作者：
通讯作者：
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影响因子：
30.8
作者：
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通讯作者：
Easton, Douglas F.
影响因子：
30.8
作者：
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通讯作者：
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影响因子：
30.8
作者：
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通讯作者：
McVean, Gil
影响因子：
30.8
作者：
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通讯作者：
Willoughby, Ernest