Aspirin use is associated with lower mammographic density in a large screening cohort.
Aspirin use is associated with lower mammographic density in a large screening cohort.
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DOI：
10.1007/s10549-017-4127-6
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发表时间：
2017-04
影响因子：
3.8
通讯作者：
Kontos D
中科院分区：
文献类型：
--
作者：
Wood ME;Sprague BL;Oustimov A;Synnstvedt MB;Cuke M;Conant EF;Kontos D
Observational and biologic studies suggest that aspirin is a promising prevention therapy for breast cancer. However, clinical trials to date have not corroborated this evidence, potentially due to study design. We evaluated the effect of aspirin on mammographic density (MD), an established modifiable risk factor for breast cancer. Electronic medical records from the University of Pennsylvania were evaluated for women who underwent screening mammography, saw their primary care provider and had a confirmed list of medications during 2012-2013. Logistic regression was performed to test for associations between clinically-recorded MD and aspirin use, after adjusting for age, body mass index (BMI) and ethnicity. We identified 26,000 eligible women. Mean age was 57.3, mean BMI was 28.9 kg/m2, 41% were African American and 19.7% reported current aspirin use. Aspirin users were significantly older and had higher BMI. There was an independent, inverse association between aspirin use and MD (Ptrend<0.001). Women with extremely dense breasts were less likely to be aspirin users than women with scattered fibroglandular density (OR=0.73; 95% CI: 0.57–0.93). This association was stronger for younger women (p=0.0002) and for African Americans (p=0.011). The likelihood of having dense breasts decreased with aspirin dose (Ptrend=0.007), suggesting a dose response. We demonstrate an independent association between aspirin use and lower MD in a large, diverse screening cohort. This association was stronger for younger and African American women: two groups at greater risk for Er- breast cancer. These results and others highlight the value of a randomized controlled trial of aspirin for prevention in premenopausal high-risk women.
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影响因子：
2.3
作者：
Brasky, Theodore M.;Bonner, Matthew R.;Moysich, Kirsten B.;Ambrosone, Christine B.;Nie, Jing;Tao, Meng Hua;Edge, Stephen B.;Kallakury, Bhaskar V. S.;Marian, Catalin;Goerlitz, David S.;Trevisan, Maurizio;Shields, Peter G.;Freudenheim, Jo L.
通讯作者：
Freudenheim, Jo L.
影响因子：
4.7
作者：
Boyd, N F;Martin, L J;Yaffe, M J
通讯作者：
Yaffe, M J
DOI：
10.1093/jnci/91.16.1404
发表时间：
1999-08-18
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Boyd, NF;Lockwood, GA;Tritchler, DL
通讯作者：
Tritchler, DL
影响因子：
168.9
作者：
Cuzick, Jack;Sestak, Ivana;Howell, Anthony
通讯作者：
Howell, Anthony
DOI：
10.1093/jnci/87.9.670
发表时间：
1995-05-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BOYD, NF;BYNG, JW;YAFFE, MJ
通讯作者：
YAFFE, MJ