Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma.
Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma.
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DOI：
10.1038/mi.2012.14
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发表时间：
2012-05
影响因子：
8
通讯作者：
Ziegler, S. F.
中科院分区：
文献类型：
--
作者：
Han, H.;Xu, W.;Headley, M. B.;Jessup, H. K.;Lee, K. S.;Omori, M.;Comeau, M. R.;Marshak-Rothstein, A.;Ziegler, S. F.
患有一种特应性疾病的个体更有可能患上第二种。大约一半的特应性皮炎（AD）患者随后发展为哮喘，特别是那些重度AD患者。这种关联，表明AD作为后续过敏性疾病的切入点的作用，是一种被称为“特应性进行曲”的现象。虽然特应性进行曲的根本原因仍然未知，但最近的证据表明细胞因子TSLP的作用。我们已经建立了一个小鼠模型，以确定是否TSLP在这种现象中发挥作用，并在这项研究中表明，小鼠暴露于抗原OVA在皮肤中的TSLP的存在下，发展严重的气道炎症时，后来用相同的抗原在肺中的挑战。有趣的是，肺中TSLP的产生和循环TSLP都不需要加重随后抗原激发诱导的哮喘。然而，在应答的激发阶段需要CD4 T细胞，正如用致敏抗原激发一样，证明应答是抗原特异性的。这项研究提供了一个干净的小鼠模型来研究人类特应性行军，表明皮肤来源的TSLP可能是触发从特应性皮炎发展为哮喘的重要因素。
Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as the ‘atopic march’. While the underlying cause of the atopic march remains unknown, recent evidence suggests a role for the cytokine TSLP. We have established a mouse model to determine whether TSLP plays a role in this phenomenon, and in this study show that mice exposed to the antigen OVA in the skin in the presence of TSLP develop severe airway inflammation when later challenged with the same antigen in the lung. Interestingly, neither TSLP production in the lung nor circulating TSLP is required to aggravate the asthma that was induced upon subsequent antigen challenge. However, CD4 T cells are required in the challenge phase of the response, as was challenge with the sensitizing antigen, demonstrating that the response was antigen-specific. This study, which provides a clean mouse model to study human atopic march, indicates that skin-derived TSLP may represent an important factor that triggers progression from atopic dermatitis to asthma.
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影响因子：
6.1
作者：
Kulig, M;Bergmann, R;Wahn, U
通讯作者：
Wahn, U
影响因子：
14.2
作者：
Kihlström, A;Lilja, G;Hedlin, G
通讯作者：
Hedlin, G
影响因子：
4.4
作者：
Jessup, Heidi K.;Brewer, Avery W.;Comeau, Michael R.
通讯作者：
Comeau, Michael R.
影响因子：
4.4
作者：
Reche, PA;Soumelis, V;Bazan, JF
通讯作者：
Bazan, JF
影响因子：
5.4
作者：
Ray, RJ;Furlonger, C;Paige, CJ
通讯作者：
Paige, CJ