The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis.
The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis.
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DOI：
10.3389/fphys.2021.807685
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发表时间：
2021
影响因子：
4
通讯作者：
Osteen KG
中科院分区：
文献类型：
--
作者：
Stephens VR;Rumph JT;Ameli S;Bruner-Tran KL;Osteen KG
患有子宫内膜异位症的妇女，子宫内膜腺体和子宫外基质的生长，通常也表现出子宫腺肌病，子宫内膜组织在子宫肌肉内的生长。每种疾病都与在位子宫内膜的功能改变有关，经常导致疼痛、生育能力降低和不良妊娠结局风险增加。虽然这两种疾病的确切病因尚不清楚，但有证据表明，子宫内膜异位症的存在可能是子宫腺肌病随后发展的一个促成因素，其结果是改变了全身炎症反应。在此，我们将讨论暴露于具有内分泌干扰能力的环境毒物在子宫内膜异位症和子宫腺肌病发病机制中的潜在作用。许多流行病学和实验研究支持环境内分泌干扰物（EDCs）在子宫内膜异位症的发展中的作用;然而，只有少数研究研究了有毒物质暴露与子宫腺肌病风险之间的潜在关系。然而，由于子宫内膜异位症的妇女也经常发现有子宫腺肌病，讨论EDC暴露和这些疾病的发展是相关的。我们将讨论内分泌干扰物可能促进子宫内膜异位症和子宫腺肌病共同发展的潜在机制。了解与子宫内膜异位症和子宫腺肌病相关的环境毒物的疾病促进机制对于设计更有效的治疗和预防策略至关重要。
Women with endometriosis, the growth of endometrial glands and stroma outside the uterus, commonly also exhibit adenomyosis, the growth of endometrial tissues within the uterine muscle. Each disease is associated with functional alterations in the eutopic endometrium frequently leading to pain, reduced fertility, and an increased risk of adverse pregnancy outcomes. Although the precise etiology of either disease is poorly understood, evidence suggests that the presence of endometriosis may be a contributing factor to the subsequent development of adenomyosis as a consequence of an altered, systemic inflammatory response. Herein, we will discuss the potential role of exposure to environmental toxicants with endocrine disrupting capabilities in the pathogenesis of both endometriosis and adenomyosis. Numerous epidemiology and experimental studies support a role for environmental endocrine disrupting chemicals (EDCs) in the development of endometriosis; however, only a few studies have examined the potential relationship between toxicant exposures and the risk of adenomyosis. Nevertheless, since women with endometriosis are also frequently found to have adenomyosis, discussion of EDC exposure and development of each of these diseases is relevant. We will discuss the potential mechanisms by which EDCs may act to promote the co-development of endometriosis and adenomyosis. Understanding the disease-promoting mechanisms of environmental toxicants related to endometriosis and adenomyosis is paramount to designing more effective treatment(s) and preventative strategies.
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影响因子：
0.5
作者：
Bruner-Tran, Kaylon L;Resuehr, David;Ding, Tianbing;Lucas, John A;Osteen, Kevin G
通讯作者：
Osteen, Kevin G
影响因子：
6.7
作者：
Aldad, Tamir S.;Rahmani, Nora;Leranth, Csaba;Taylor, Hugh S.
通讯作者：
Taylor, Hugh S.
DOI：
10.1080/07315724.2004.10719428
发表时间：
2004-12-01
影响因子：
3.5
作者：
Barker, DJP
通讯作者：
Barker, DJP
影响因子：
3.6
作者：
Bruner-Tran KL;Duleba AJ;Taylor HS;Osteen KG
通讯作者：
Osteen KG
DOI：
10.4103/0971-5916.155594
发表时间：
2015-02
期刊：
The Indian journal of medical research
影响因子：
--
作者：
Benagiano G;Brosens I;Lippi D
通讯作者：
Lippi D