Anti-Inflammatory Properties and Gut Microbiota Modulation of Porphyra tenera Extracts in Dextran Sodium Sulfate-Induced Colitis in Mice.
Anti-Inflammatory Properties and Gut Microbiota Modulation of Porphyra tenera Extracts in Dextran Sodium Sulfate-Induced Colitis in Mice.
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条斑紫菜提取物在葡聚糖硫酸钠诱导的小鼠结肠炎中的抗炎特性及对肠道微生物群的调节作用
DOI：
10.3390/antiox9100988
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发表时间：
2020-10-14
期刊：
影响因子：
--
通讯作者：
Unno T
中科院分区：
文献类型：
--
作者：
Kim J;Choi JH;Ko G;Jo H;Oh T;Ahn B;Unno T
淡紫菜 (PT) 是一种功能性海藻食品，据报道具有抗氧化、免疫刺激、抗炎和保肝等健康益处。在这项研究中，我们研究了 PT 提取物对结肠炎诱导小鼠肠道微生物群调节的影响。小鼠实验设计为三组，包括正常小鼠（CTL）、右旋糖酐硫酸钠（DSS）喂养的小鼠和DSS加PT提取物喂养的小鼠（PTE）。通过饮用含有DSS的水给予DSS 1周，并将PT提取物摄入小鼠胃肠道。 PT提取物改善了体重和结肠长度的下降，并改善了疾病活动指数和促炎细胞因子的表达。此外，PT 提取物显着改变了小鼠的肠道微生物群。 DSS 处理显着增加了有害细菌（即螺杆菌、Mucipirillum 和 Parasutterella）的比例，并减少了产生丁酸盐的细菌（即 Acetatifactor、Alistipes、Oscillibacter 和 Clostridium_XIVb）。 PT 提取物增加了 Clostridium_XIVb 属的丰度，并丰富了一些预测的代谢活动，如乙醛酸循环、乙基丙二酰辅酶 A 途径、硝酸盐还原、肌酐降解和甘氨酸甜菜碱代谢。这些结果表明，PT 提取物可能通过调节小鼠肠道微生物群的组成和功能来改善 DSS 诱导的结肠炎炎症。
Porphyra tenera (PT) is a functional seaweed food that has been reported for health benefits such as antioxidant, immunostimulant, anti-inflammation, and hepatoprotective effects. In this study, we investigated the effect of PT extracts on gut microbiota modulation in colitis-induced mice. The mice experiment was designed as three groups including normal mice (CTL), dextran sodium sulfate (DSS)-fed mice, and DSS plus PT extracts-fed mice (PTE). DSS was administrated through drinking water containing DSS for 1 week, and the PT extract was ingested into the gastrointestinal tract in mice. PT extract ameliorated the decreased body weight and colon length and improved disease activity index and pro-inflammatory cytokine expression. In addition, PT extract significantly shifted the gut microbiota of mice. DSS treatment significantly increased the portion of harmful bacteria (i.e., Helicobacter, Mucipirillum, and Parasutterella) and decreased the butyrate producing bacteria (i.e., Acetatifactor, Alistipes, Oscillibacter, and Clostridium_XIVb). PT extract increased the abundance of genera Clostridium_XIVb and also enriched some of predicted metabolic activities such as glyoxylate cycle, ethylmalonyl-CoA pathway, nitrate reduction, creatinine degradation, and glycine betaine metabolism. These results suggest that PT extract may ameliorate the DSS-induced colitis inflammation through regulating the compositions and functions of gut microbiota in mice.
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DOI：
10.1155/2014/928461
发表时间：
2014
期刊：
ISRN inflammation
影响因子：
--
作者：
Gálvez J
通讯作者：
Gálvez J
影响因子：
3.9
作者：
Gacesa R;Lawrence KP;Georgakopoulos ND;Yabe K;Dunlap WC;Barlow DJ;Wells G;Young AR;Long PF
通讯作者：
Long PF
影响因子：
7
作者：
Corsetto, Paola Antonia;Montorfano, Gigliola;Rizzo, Angela Maria
通讯作者：
Rizzo, Angela Maria
影响因子：
6.1
作者：
Dudonne, Stephanie;Vitrac, Xavier;Merillon, Jean-Michel
通讯作者：
Merillon, Jean-Michel
影响因子：
15.5
作者：
Fernandes AD;Reid JN;Macklaim JM;McMurrough TA;Edgell DR;Gloor GB
通讯作者：
Gloor GB