Genetic susceptibility to Chagas disease: an overview about the infection and about the association between disease and the immune response genes.
Genetic susceptibility to Chagas disease: an overview about the infection and about the association between disease and the immune response genes.
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DOI：
10.1155/2013/284729
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发表时间：
2013
影响因子：
--
通讯作者：
Sell AM
中科院分区：
文献类型：
--
作者：
Ayo CM;Dalalio MM;Visentainer JE;Reis PG;Sippert EÂ;Jarduli LR;Alves HV;Sell AM
恰加斯病是由鞭毛虫寄生虫克氏锥虫引起的，影响拉丁美洲的 8-1000 万人。该疾病是地方性的，其特征是急性和慢性阶段，以不确定的、心脏的和/或胃肠道的形式发展。尽管人类克氏锥虫感染期间的免疫反应在推动慢性感染的独特临床表现的发展中发挥着作用，但其作用尚不完全清楚。涉及先天性和特异性免疫反应的基因多态性正在被广泛研究，以阐明它们在疾病发生或严重程度中可能发挥的作用。本文综述了经典和非经典MHC、KIR和细胞因子宿主遗传因素在克氏锥虫感染和恰加斯病临床病程中的作用。
Chagas disease, which is caused by the flagellate parasite Trypanosoma cruzi, affects 8–10 million people in Latin America. The disease is endemic and is characterised by acute and chronic phases that develop in the indeterminate, cardiac, and/or gastrointestinal forms. The immune response during human T. cruzi infection is not completely understood, despite its role in driving the development of distinct clinical manifestations of chronic infection. Polymorphisms in genes involved in the innate and specific immune response are being widely studied in order to clarify their possible role in the occurrence or severity of disease. Here we review the role of classic and nonclassic MHC, KIR, and cytokine host genetic factors on the infection by T. cruzi and the clinical course of Chagas disease.
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影响因子：
56.9
作者：
Bauer, S;Groh, V;Spies, T
通讯作者：
Spies, T
影响因子：
5.9
作者：
BEAN, WB
通讯作者：
BEAN, WB
影响因子：
8.4
作者：
Alessio Franceschi, Danilo Santana;Mazini, Priscila Saamara;Laguila Visentainer, Jeane Eliete
通讯作者：
Laguila Visentainer, Jeane Eliete
DOI：
10.1073/pnas.91.14.6259
发表时间：
1994-07-05
影响因子：
11.1
作者：
BAHRAM, S;BRESNAHAN, M;SPIES, T
通讯作者：
SPIES, T
影响因子：
--
作者：
Calzada, JE;Nieto, A;Martín, J
通讯作者：
Martín, J