Roles for the coactivators CBP and p300 and the APC/C E3 ubiquitin ligase in E1A-dependent cell transformation.
Roles for the coactivators CBP and p300 and the APC/C E3 ubiquitin ligase in E1A-dependent cell transformation.
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DOI：
10.1038/sj.bjc.6603304
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发表时间：
2006-09-04
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
当腺病毒早期1A区（E1A）与激活的ras或E1B基因在体外组织培养系统（如胚胎人视网膜神经上皮细胞或胚胎啮齿动物上皮细胞和成纤维细胞）中表达时，具有强大的转化活性。因此，早期1A区已被广泛而有效地用作确定细胞转化基础的分子机制的工具。在这方面，e1a结合蛋白pRb， p107, p130，环AMP反应元件结合蛋白(CBP)/p300, p400， TRRAP和CtBP在细胞转化中的作用已经确定。然而，E1A通过与这些伙伴蛋白相互作用促进转化的机制尚未完全描述。在这篇综述中，我们重点介绍了我们对CBP/p300功能的最新了解，特别是关于其与后期促进复合物/环体E3泛素连接酶的关系，最近被证明通过在E1A中进化保守的相互作用域相互作用并影响CBP/p300的活性。
Adenovirus early region 1A (E1A) possesses potent transforming activity when expressed in concert with activated ras or E1B genes in in vitro tissue culture systems such as embryonic human retinal neuroepithelial cells or embryonic rodent epithelial and fibroblast cells. Early region 1A has thus been used extensively and very effectively as a tool to determine the molecular mechanisms that underlie the basis of cellular transformation. In this regard, roles for the E1A-binding proteins pRb, p107, p130, cyclic AMP response element-binding protein (CBP)/p300, p400, TRRAP and CtBP in cellular transformation have been established. However, the mechanisms by which E1A promotes transformation through interaction with these partner proteins are not fully delineated. In this review, we focus on recent advances in our understanding of CBP/p300 function, particularly with regard to its relationship to the anaphase-promoting complex/cyclosome E3 ubiquitin ligase, which has recently been shown to interact and affect the activity of CBP/p300 through interaction domains that are evolutionarily conserved in E1A.
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影响因子：
8
作者：
Grooteclaes, ML;Frisch, SM
通讯作者：
Frisch, SM
影响因子：
3.8
作者：
CAPOROSSI, D;BACCHETTI, S
通讯作者：
BACCHETTI, S
影响因子：
5.6
作者：
MURRAY, JD;BELLETT, AJD;TAYLOR, IW
通讯作者：
TAYLOR, IW
影响因子：
56.9
作者：
TRENTIN, JJ;TAYLOR, G;YABE, Y
通讯作者：
YABE, Y
影响因子：
10.5
作者：
ECKNER, R;EWEN, ME;LIVINGSTON, DM
通讯作者：
LIVINGSTON, DM