Association of number of retrieved oocytes with live birth rate and birth weight: an analysis of 231,815 cycles of in vitro fertilization.
Association of number of retrieved oocytes with live birth rate and birth weight: an analysis of 231,815 cycles of in vitro fertilization.
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DOI：
10.1016/j.fertnstert.2014.12.120
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发表时间：
2015-04
影响因子：
6.7
通讯作者：
Conrad, Kirk P.
中科院分区：
文献类型：
--
作者：
Baker, Valerie L.;Brown, Morton B.;Luke, Barbara;Conrad, Kirk P.
目的探讨卵母细胞数量与活产率和低出生体重（LBW）发生率的相关性。回顾性队列。N/A。使用自体（n=194,627）或供体（n=37,188）卵母细胞进行新鲜胚胎移植的妇女，其周期报告于2004-2010年辅助生殖技术协会。活产率，出生体重，出生体重z分数，LBW。没有。对于自体卵母细胞和供体卵母细胞周期，在所有模型中进行的大多数分析中，提取的卵母细胞数量的增加与活产率和可用于冷冻保存的胚胎平行，这些模型根据年龄和以前的出生进行了调整。对于通过移植2个胚胎使用自体卵母细胞实现单胎妊娠的周期，获得的卵母细胞数量越多，平均出生体重越低，出生体重z-score越低，LBW发病率越高。相反，对于使用供体卵母细胞的周期，检索到的卵母细胞数量与出生体重没有关联。在移植2个胚胎而非供体卵母细胞周期的自体单胎妊娠中，获得的卵母细胞数量越多，LBW的发生率就越高。虽然高卵母细胞数量对自体周期中LBW发生率的影响不大，但需要进一步研究以确定是否有一个妇女亚群特别容易受到影响。
To determine if number of oocytes correlates with live birth rate and incidence of low birthweight (LBW). Retrospective cohort. N/A. Women undergoing fresh embryo transfer utilizing either autologous (n=194,627) or donor (n=37,188) oocytes whose cycles were reported to the Society for Assisted Reproductive Technology 2004–2010. Live birth rate, birthweight, birth weight z-score, LBW. None. For both autologous and donor oocyte cycles, increasing number of oocytes retrieved paralleled live birth rate and embryos available for cryopreservation in most analyses performed with all models adjusted for age and prior births. For cycles achieving singleton pregnancy using autologous oocytes via transfer of 2 embryos, a higher number of oocytes retrieved was associated with lower mean birth weight, lower birthweight z-score, and greater incidence of LBW. In contrast, for cycles using donor oocytes, there was no association of oocyte number retrieved with measures of birthweight. A higher number of oocytes retrieved was associated with an increased incidence of LBW in autologous singleton pregnancies resulting from transfer of 2 embryos but not in donor oocyte cycles. Although the effect of high oocyte number on the incidence of LBW in autologous cycles was of modest magnitude, further study is warranted to determine if a subgroup of women may be particularly vulnerable.
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