Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3.
Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3.
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DOI：
10.1038/ncomms7846
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发表时间：
2015-04-17
影响因子：
16.6
通讯作者：
Neufeld, Thomas P.
中科院分区：
文献类型：
--
作者：
Kim, Jung;Neufeld, Thomas P.
胰岛素家族的分泌配体促进细胞生长并维持糖稳态。胰岛素的释放受到饮食条件的严格调节，但胰岛素产生细胞（IPC）如何协调它们对不同营养信号的反应尚不清楚。在这里，我们表明，调节果蝇幼虫的胰岛素分泌已被分离成不同的分支：而氨基酸促进果蝇胰岛素样肽2（Dilp2）的分泌，循环糖促进Dilp3的选择性释放。Dilp3是糖介导的TOR信号传导激活和抑制幼虫脂肪体中自噬的独特需要。糖水平不直接感知的IPC，而是由脂肪动力激素（AKH）的心体的生产细胞，我们证明，AKH信号是必需的糖依赖性Dilp3释放的IPC。因此，IPC整合多种信号以调节不同营养条件下不同胰岛素亚型的分泌。
Secreted ligands of the insulin family promote cell growth and maintain sugar homeostasis. Insulin release is tightly regulated in response to dietary conditions, but how insulin producing cells (IPCs) coordinate their responses to distinct nutrient signals is unclear. Here, we show that regulation of insulin secretion in Drosophila larvae has been segregated into distinct branches: whereas amino acids promote secretion of Drosophila insulin-like peptide 2 (Dilp2), circulating sugars promote selective release of Dilp3. Dilp3 is uniquely required for sugar-mediated activation of TOR signaling and suppression of autophagy in the larval fat body. Sugar levels are not sensed directly by the IPCs, but rather by the adipokinetic hormone (AKH)-producing cells of the corpora cardiaca, and we demonstrate that AKH signaling is required in the IPCs for sugar-dependent Dilp3 release. Thus, IPCs integrate multiple cues to regulate secretion of distinct insulin subtypes under varying nutrient conditions.
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影响因子：
9.8
作者：
Grönke S;Müller G;Hirsch J;Fellert S;Andreou A;Haase T;Jäckle H;Kühnlein RP
通讯作者：
Kühnlein RP
影响因子：
64.5
作者：
Rajan A;Perrimon N
通讯作者：
Perrimon N
影响因子：
3.7
作者：
Crivat, Georgeta;Lizunov, Vladimir A.;Pick, Leslie
通讯作者：
Pick, Leslie
影响因子：
3.3
作者：
Lee, GH;Park, JH
通讯作者：
Park, JH
DOI：
10.1007/bf01919312
发表时间：
1996-05-01
期刊：
EXPERIENTIA
影响因子：
--
作者：
Becker, A;Schloder, P;Wegener, G
通讯作者：
Wegener, G