Preparation, characterization and toxicity evaluation of amphotericin B loaded MPEG-PCL micelles and its application for buccal tablets
Preparation, characterization and toxicity evaluation of amphotericin B loaded MPEG-PCL micelles and its application for buccal tablets
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两性霉素B MPEG-PCL胶束的制备、表征、毒性评价及其口含片的应用
DOI：
10.1007/s00253-017-8463-6
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发表时间：
2017-09
影响因子：
5
通讯作者：
Lin Rong
中科院分区：
文献类型：
--
作者：
Zhang Peipei;Yang Xiaofeng;He Yanhao;Chen Zhuo;Liu Bing;Emesto Cota Segura;Yang Guangde;Wang Weirong;Zhang Jiye;Lin Rong
Oral candidiasis or thrush is a fungal infection due toCandida albicans, causing discomfort in areas inside mouth or tongue. The clinical application of antifungal reagent amphotericin B (AMB), which is believed to offer a better treatment for oral candidiasis, is greatly compromised by its toxicities (mainly nephrotoxicity) and poor solubility. In order to overcome these issues, we characterized AMB-loaded MPEG-PCL micelles in vitro and in vivo. In addition, the antifungal activities of AMB/MPEG-PCL micelles-loaded buccal tablet were also evaluated in vitro. We found that micelles system could significantly improve the solubility of AMB yet reduce the overall toxicity, while the buccal tablet system is capable to suppressC. albicansbiofilm formation. Furthermore, the toxicity of the buccal tablet system is also reduced compared with other standard preparations. Therefore, the prepared tablet with AMB-loaded MPEG-PCL micelles as oral topical preparations has the potential to improve current treatment of superficial oralC. albicansinfections.
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