The heterogeneity of the biliary tree.
The heterogeneity of the biliary tree.
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DOI：
10.1016/j.jhep.2021.04.016
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发表时间：
2021-11
影响因子：
25.7
通讯作者：
Porte, Robert J.
中科院分区：
文献类型：
--
作者：
de Jong, Iris E. M.;van den Heuvel, Marius C.;Walls, Rebecca G.;Porte, Robert J.
胆道树和肝脏是密不可分的。它们是相辅相成的，通常被认为是一个器官。然而，胆道树有自己明确的身份。此外，如果你仔细观察，在这个胆管网络内，结构、功能和胚胎学上的变异是惊人的。肝细胞胆小管位于胆管树的最近端，过渡到Hering(CoH)管，其中含有前体细胞，胆管细胞与肝细胞并列在一起。胆汁从胆总管流入胆管(直径15μm)，并通过胆管合并网络(直径从15μm增加到几毫米)进入十二指肠(大小适用于人体胆管)。胆管细胞数量从近端到远端变化：通常，小叶间和间隔导管内排列着小的胆管细胞，而大的肝内、肝段、肝管和胆总管内排列着大的胆管细胞(2)。随着胆管直径的增加，胞浆到胞浆
The biliary tree and the liver are inseparably linked. They complement each other and are generally considered one organ. However, the biliary tree has a well-defined identity of its own. Moreover, if you look closely, an astonishing number of structural, functional, and embryological variation is evident within this ductular network.Grossly, the heterogeneity of the biliary tree can be appreciated along both the proximalto-distal axis and the radial axis (1). Hepatocyte bile canaliculi are located at the most proximal end of the biliary tree and transition into the canals of Hering (CoH), which contains progenitor cells and where cholangiocytes are juxtaposed to hepatocytes. From the CoH, bile flows into the ductules (< 15 μm diameter) and through the merging network of ducts (increasing in size from 15 μm to several mm in diameter) into the duodenum (sizes apply to the human bile duct). The cholangiocyte population changes from proximal to distal: generally, the interlobular and septal ducts are lined with small cholangiocytes while the large intrahepatic, segmental, and hepatic ducts and the common bile duct are lined with large cholangiocytes (2). As bile duct diameter increases, the cytoplasm-to-
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DOI：
10.1002/ar.a.20089
发表时间：
2004-09-01
期刊：
ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY
影响因子：
--
作者：
Balemba, OB;Salter, MJ;Mawe, GM
通讯作者：
Mawe, GM
影响因子：
13.5
作者：
Carpino, Guido;Nevi, Lorenzo;Gaudio, Eugenio
通讯作者：
Gaudio, Eugenio
影响因子：
13.5
作者：
de Jong, Iris E. M.;Matton, Alix P. M.;Porte, Robert J.
通讯作者：
Porte, Robert J.
DOI：
10.1007/bf00749679
发表时间：
1988-01-01
期刊：
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
影响因子：
--
作者：
TERADA, T;NAKANUMA, Y
通讯作者：
NAKANUMA, Y
影响因子：
13.5
作者：
DESMET, VJ
通讯作者：
DESMET, VJ