Ultrastructural and immunohistochemical features of coronal adenomas.

Ultrastructural and immunohistochemical features of coronal adenomas.
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冠状腺瘤的超微结构和免疫组织化学特征。

DOI:
10.1016/s0002-9394(14)76209-9
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发表时间:
1991
影响因子:
4.2
通讯作者:
Foos,RY
Foos,RY
中科院分区:
医学1区
文献类型:
--
作者:
Brown,HH;Glasgow,BJ;Foos,RY

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我们通过电子显微镜研究了三个冠状腺瘤偶然发现的眼睛手术切除。肿瘤细胞表现出明显的细胞间相互交错,有大量桥粒、线粒体、丰富的粗面内质网和细胞核,细胞核内有膜折叠和颗粒状染色质。在这些特征中,肿瘤细胞与睫状突的非色素睫状上皮细胞相同。这些生长物含有丰富的细胞外物质,表现为复杂的重叠基膜和无结构的颗粒区的二型模式。福尔马林固定,石蜡包埋的冠状腺瘤的免疫组化研究表明,IV型胶原和层粘连蛋白的细胞外材料。这些发现证实了冠状腺瘤是由无色素的睫状上皮细胞发展而来的,并且这些肿瘤的细胞外物质含有通常存在于基底膜中的成分。
We studied by electron microscopy three coronal adenomas discovered incidentally in eyes removed surgically. Tumor cells displayed prominent intercellular interdigitations with numerous desmosomes, mitochondria, abundant rough endoplasmic reticulum, and nuclei with membrane infoldings and a granular chromatin pattern. In these characteristics, the tumor cells were identical to nonpigmented ciliary epithelium of the ciliary processes. These growths contained abundant extracellular material, which showed a dimorphic pattern of complex reduplicated basal lamina and granular areas without structure. Immunohistochemical studies on formalin-fixed, paraffin-embedded coronal adenomas demonstrated type IV collagen and laminin in the extracellular material. These findings confirm that coronal adenomas develop from nonpigmented ciliary epithelium and that the extracellular material of these tumors contains components normally present in basement membranes.
视网膜睫状体肿瘤。
DOI: 10.1016/0002-9394(61)90151-9
发表时间: 1961
影响因子: 4.2
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