24-hour profile of serum sclerostin and its association with bone biomarkers in men.
24-hour profile of serum sclerostin and its association with bone biomarkers in men.
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DOI：
10.1007/s00198-017-4162-5
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Buxton OM
中科院分区：
文献类型：
--
作者：
Swanson C;Shea SA;Wolfe P;Markwardt S;Cain SW;Munch M;Czeisler CA;Orwoll ES;Buxton OM
骨细胞在骨重建中发挥重要作用，但其节律性和对其他骨细胞节律的影响尚未完全表征。本研究的目的是确定血清sclerostin是否在24小时（h）间隔内显示节律性，与其他骨生物标志物相似。对10名年龄在20-65岁之间的健康男性每2小时测量一次血清硬化素、FGF-23、CTX和P1 NP，间隔24小时。使用重复测量模型中参数的最大似然估计来确定这些生物标志物是否显示昼夜正弦节律。硬化蛋白（p = 0.99）或P1 NP（p = 0.65）未发现明显的24小时节律。确认了CTX节律性（p < 0.001），在05：30达到峰值（范围01：30-07：30）。FGF-23水平也是有节律的（p < 0.001），但峰值时间是可变的（范围02：30-11：30）。在这四种骨生物标志物之间确定的唯一显著相关性是CTX和P1 NP平均24小时代谢物水平（r = 0.65，p = 0.04）。硬化素水平在男性中似乎没有节奏。这表明与CTX相反，血清硬化蛋白可以在一天中的任何时间测量。FGF-23的24小时曲线表明，骨细胞功能的一个组成部分是有节奏的，但其时间是可变的。我们的研究结果不支持骨细胞指导其他骨转换标志物（CTX）的节律性的假设，至少不是通过sclerostin介导的机制。
The osteocyte exerts important effects on bone remodeling but its rhythmicity and effect on the rhythms of other bone cells are not fully characterized. The purpose of this study was to determine if serum sclerostin displays rhythmicity over a 24-hour (h) interval, similar to that of other bone biomarkers. Serum sclerostin, FGF-23, CTX, and P1NP were measured every 2 hours over a 24-h interval on 10 healthy men aged 20-65 years. Maximum likelihood estimates of the parameters in a repeated measures model were used to determine if these biomarkers displayed a diurnal, sinusoidal rhythm. No discernible 24-h rhythm was identified for sclerostin (p = 0.99) or P1NP (p = 0.65). CTX rhythmicity was confirmed (p < 0.001), peaking at 05:30 (range 01:30–07:30). FGF-23 levels were also rhythmic (p < 0.001) but time of peak was variable (range 02:30-11:30). The only significant association identified between these four bone biomarkers was for CTX and P1NP mean 24-h metabolite levels (r = 0.65, p = 0.04). Sclerostin levels do not appear to be rhythmic in men. This suggests that in contrast to CTX, serum sclerostin could be measured at any time of day. The 24-h profiles of FGF-23 suggest that a component of osteocyte function is rhythmic but its timing is variable. Our results do not support the hypothesis that osteocytes direct the rhythmicity of other bone turnover markers (CTX), at least not via a sclerostin mediated mechanism.
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