Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion.
Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion.
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DOI：
10.1016/j.neuroimage.2011.10.018
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发表时间：
2012-02-01
期刊：
影响因子：
5.7
通讯作者：
Petersen, Steven E.
中科院分区：
文献类型：
--
作者：
Power, Jonathan D.;Barnes, Kelly A.;Snyder, Abraham Z.;Schlaggar, Bradley L.;Petersen, Steven E.
在这里，我们证明，尽管补偿空间配准和运动估计的回归，对象运动在静息状态功能连通性MRI(Rs-fcMRI)数据的时间过程中产生了实质性的变化。这些变化导致了整个大脑系统但虚假的关联结构。具体地说，许多远距离相关性因被试运动而降低，而许多短距离相关性则增加。RS-FcMRI相关性中的这些变化既不是由一些常见的功能连接性处理步骤引起的，也不是由它们充分抵消的。提出了两个数据质量指标，并展示了一种在RS-fcMRI分析中减少运动相关效应的简单方法，该方法应该可以在各种软件平台上灵活地实现。我们演示了这项技术的应用如何影响我们自己的数据，修正了之前关于大脑发育的结论。这些结果表明，在处理受试者运动时需要更加小心，并且需要批判性地重新审视以前可能没有充分控制短暂受试者运动的影响的rs-fcMRI工作。
Here, we demonstrate that subject motion produces substantial changes in the timecourses of resting state functional connectivity MRI (rs-fcMRI) data despite compensatory spatial registration and regression of motion estimates from the data. These changes cause systematic but spurious correlation structures throughout the brain. Specifically, many long-distance correlations are decreased by subject motion, whereas many short-distance correlations are increased. These changes in rs-fcMRI correlations do not arise from, nor are they adequately countered by, some common functional connectivity processing steps. Two indices of data quality are proposed, and a simple method to reduce motion-related effects in rs-fcMRI analyses is demonstrated that should be flexibly implementable across a variety of software platforms. We demonstrate how application of this technique impacts our own data, modifying previous conclusions about brain development. These results suggest the need for greater care in dealing with subject motion, and the need to critically revisit previous rs-fcMRI work that may not have adequately controlled for effects of transient subject movements.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1007/978-1-60327-919-2_14
发表时间：
2009-01-01
期刊：
FMRI TECHNIQUES AND PROTOCOLS
影响因子：
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作者：
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通讯作者：
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影响因子：
16.2
作者：
Power, Jonathan D.;Fair, Damien A.;Schlaggar, Bradley L.;Petersen, Steven E.
通讯作者：
Petersen, Steven E.
影响因子：
5.7
作者：
Beckmann, CF;Smith, SM
通讯作者：
Smith, SM
影响因子：
5.7
作者：
Jones, Tyler B.;Bandettini, Peter A.;Kenworthy, Lauren;Case, Laura K.;Milleville, Shawn C.;Martin, Alex;Birn, Rasmus M.
通讯作者：
Birn, Rasmus M.