Topography of cortical thinning in the Lewy body diseases.
Topography of cortical thinning in the Lewy body diseases.
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路易体疾病中皮质变薄的地形。
DOI：
10.1016/j.nicl.2020.102196
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Gomperts,StephenN
中科院分区：
文献类型：
--
作者：
Ye,Rong;Touroutoglou,Alexandra;Brickhouse,Michael;Katz,Samantha;Growdon,JohnH;Johnson,KeithA;Dickerson,BradfordC;Gomperts,StephenN
目的路易体痴呆（DLB）和帕金森病痴呆（PDD）的局部皮质变薄可能是其临床功能障碍的某些原因；皮层萎缩可能反映了广泛的路易体病理伴α -突触核蛋白沉积，以及相关的阿尔茨海默病共病理。在此，我们研究了与认知正常的PD和健康的非PD对照者相比，这些路易体疾病患者皮层变薄的地形分布，探讨了区域变薄与临床特征的关系，并评估了淀粉样蛋白沉积的影响。方法对21例路易体痴呆（DLB）患者、16例帕金森病（PD）相关认知障碍（PD- mci和PDD）患者和24例认知正常的PD患者进行MRI、PiB PET和临床评价。在诊断组和按淀粉样蛋白状态分层的亚组之间比较整个大脑和感兴趣区域（roi）的皮质厚度，并与临床和认知测量相关。结果dlb和pd受损组的皮质变薄分布相似，包括AD的特征区域，以及梭状回、中央前和中央旁回。在有选择地影响DLB参与者内侧颞叶的重叠地形中，DLB和pd受损而非pd正常参与者的PiB保留升高与更广泛和严重的皮质变薄相关。在DLB中，AD特征区和梭状回区更大的变薄与更大的认知障碍相关。结论DLB和pd相关认知障碍的皮质变薄模式相似，与AD特征区重叠并扩展到梭状回、中央前区和中央旁区。在这些疾病中，AD特征区和梭状回区的皮质变薄反映了认知障碍，并且淀粉样蛋白共同病理明显加重了认知障碍。需要进一步的工作来确定DLB和pd相关认知障碍中皮层变薄的独特地形是否可能在临床试验中作为诊断和/或结果的生物标志物具有价值。
ObjectiveRegional cortical thinning in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) may underlie some aspect of their clinical impairments; cortical atrophy likely reflects extensive Lewy body pathology with alpha-synuclein deposits, as well as associated Alzheimer's disease co-pathologies, when present. Here we investigated the topographic distribution of cortical thinning in these Lewy body diseases compared to cognitively normal PD and healthy non-PD control subjects, explored the association of regional thinning with clinical features and evaluated the impact of amyloid deposition.MethodsTwenty-one participants with dementia with Lewy bodies (DLB), 16 with Parkinson disease (PD) - associated cognitive impairment (PD-MCI and PDD), and 24 cognitively normal participants with PD underwent MRI, PiB PET, and clinical evaluation. Cortical thickness across the brain and in regions of interest (ROIs) was compared across diagnostic groups and across subgroups stratified by amyloid status, and was related to clinical and cognitive measures.ResultsDLB and PD-impaired groups shared a similar distribution of cortical thinning that included regions characteristic of AD, as well as the fusiform, precentral, and paracentral gyri. Elevated PiB retention in DLB and PD-impaired but not in PD-normal participants was associated with more extensive and severe cortical thinning, in an overlapping topography that selectively affected the medial temporal lobe in DLB participants. In DLB, greater thinning in AD signature and fusiform regions was associated with greater cognitive impairment.ConclusionsThe pattern of cortical thinning is similar in DLB and PD-associated cognitive impairment, overlapping with and extending beyond AD signature regions to involve fusiform, precentral, and paracentral regions. Cortical thinning in AD signature and fusiform regions in these diseases reflects cognitive impairment and is markedly accentuated by amyloid co-pathology. Further work will be required to determine whether the distinct topography of cortical thinning in DLB and PD-associated cognitive impairment might have value as a diagnostic and/ or outcome biomarker in clinical trials.
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DOI：
--
发表时间：
1987
期刊：
影响因子：
--
作者：
S. P. Brimmer;W. Fawcett;K. Kulhavy
通讯作者：
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影响因子：
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DOI：
10.1016/s0021-9673(01)96347-2
发表时间：
1983-01-01
期刊：
JOURNAL OF CHROMATOGRAPHY
影响因子：
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作者：
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DOI：
10.1002/chin.198012082
发表时间：
1979-12
期刊：
ChemInform
影响因子：
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作者：
G. McIntire;H. N. Blount
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G. McIntire;H. N. Blount
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影响因子：
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作者：
Burton De;M. Sepaniak;M. P. Maskarinec
通讯作者：
M. P. Maskarinec