Increased levels of soluble CD226 in sera accompanied by decreased membrane CD226 expression on peripheral blood mononuclear cells from cancer patients.
Increased levels of soluble CD226 in sera accompanied by decreased membrane CD226 expression on peripheral blood mononuclear cells from cancer patients.
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癌症患者血清中可溶性 CD226 水平升高，同时外周血单核细胞膜 CD226 表达降低
DOI：
10.1186/1471-2172-10-34
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发表时间：
2009-06-02
期刊：
影响因子：
3
通讯作者：
Jin B
中科院分区：
文献类型：
--
作者：
Xu Z;Zhang T;Zhuang R;Zhang Y;Jia W;Song C;Yang K;Yang A;Jin B
BackgroundAs a cellular membrane triggering receptor, CD226 is involved in the NK cell- or CTL-mediated lysis of tumor cells of different origin, including freshly isolated tumor cells and tumor cell lines. Here, we evaluated soluble CD226 (sCD226) levels in sera, and membrane CD226 (mCD226) expression on peripheral blood mononuclear cells (PBMC) from cancer patients as well as normal subjects, and demonstrated the possible function and origin of the altered sCD226, which may provide useful information for understanding the mechanisms of tumor escape and for immunodiagnosis and immunotherapy.ResultsSoluble CD226 levels in serum samples from cancer patients were significantly higher than those in healthy individuals (P< 0.001), while cancer patients exhibited lower PBMC mCD226 expression than healthy individuals (P< 0.001). CD226-Fc fusion protein could significantly inhibit the cytotoxicity of NK cells against K562 cells in a dose-dependent manner. Furthermore, three kinds of protease inhibitors could notably increase mCD226 expression on PMA-stimulated PBMCs and Jurkat cells with a decrease in the sCD226 level in the cell culture supernatant.ConclusionThese findings suggest that sCD226 might be shed from cell membranes by certain proteases, and, further, sCD226 may be used as a predictor for monitoring cancer, and more important, a possible immunotherapy target, which may be useful in clinical application.
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影响因子：
11.2
作者：
Hallermalm, K;De Geer, A;Levitskaya, J
通讯作者：
Levitskaya, J
影响因子：
20.3
作者：
Bryceson, YT;March, ME;Long, EO
通讯作者：
Long, EO
影响因子：
11.5
作者：
Ochiai, H;Moore, SA;Gromeier, M
通讯作者：
Gromeier, M
DOI：
10.1016/s0006-291x(03)01560-2
发表时间：
2003-09-12
影响因子：
3.1
作者：
Baury, W;Masson, D;Denis, MG
通讯作者：
Denis, MG
影响因子：
24.5
作者：
Masson, D;Jarry, A;Denis, MG
通讯作者：
Denis, MG