Assessment of meibomian gland function in dry eye using meibometry.
Assessment of meibomian gland function in dry eye using meibometry.
复制标题
使用睑板测量法评估干眼症的睑板腺功能。
DOI：
10.1001/archopht.117.6.723
复制
发表时间：
1999
影响因子：
--
通讯作者：
Anthony J. Bron
中科院分区：
文献类型：
--
作者：
Norihiko Yokoi;Federico Mossa;J. Tiffany;Anthony J. Bron
客观化
目的：应用测径技术研究干眼症患者的睑板腺功能。
方法
将42例临床诊断为汗腺功能障碍(MGD，n=12)、房水-泪液缺乏(AD，n=10)、MGD合并AD(n=2)、不完全性干眼(n=12)和非干眼(6眼)的干眼患者与41例健康对照组进行比较。应用了以下两种测脂技术：直接测脂(DM)和综合测脂(IM)，前者使用Meiblometer测量脂肪印迹，后者使用图像扫描和计算机密度测量。用干涉显微镜观察泪膜脂层厚度。
结果
除MGD患者外，所有受试者的印迹都是均匀的。糖尿病组的平均+/-SE读数为127.24+/-24.4，AD为306.4+/-9.2，不完全性干眼症为248.6+/-13.2，对照组为268.5+/-6.3，显示MGD组的数值低于所有其他组(P<；.001)。IM的结果相似(P<；.001，P=.01，P<；.001)。MGD组的脂层数明显低于其他组。
结论
与对照组相比，MGD患者的LID血脂水平降低，而AD患者的LID血脂水平升高。与MGD患者相比，AD患者的脂层厚度增加。这两种测压技术对评估MGD可能是有用的。虽然DM需要特殊的设备(Meiblometer)，但它提供了即时诊断价值的记录。尽管IM不如DM有效，但它提供了脂肪印记的可视记录，这本身可能具有诊断价值，并使用许多实验室提供的设备。
OBJECTIVE
To study meibomian gland function in dry eyes using meibometry.
METHODS
Forty-two patients with clinically diagnosed dry eye that was reclassified as meibomian gland dysfunction (MGD [n = 12]), aqueous-tear deficiency (AD [n = 10]), MGD combined with AD (n = 2), "incomplete" dry eye (n = 12), and non-dry eye (6 eyes) were compared with 41 healthy control subjects. The following 2 techniques of meibometry were applied: direct meibometry (DM) measuring lipid imprints using the Meibometer, and integrated meibometry (IM) using image-scanning and computer densitometry. Tear film lipid layer thickness was assessed using interference microscopy.
RESULTS
Imprints were homogeneous for all subjects except those with MGD. Mean+/-SE readings on results of DM were 127.24+/-24.4 for MGD, 306.4+/-9.2 for AD, 248.6+/-13.2 for incomplete dry eye, and 268.5+/-6.3 for controls, showing lower values in the MGD group relative to all others (P<.001). Results of IM gave similar results (P<.001, P =.01, and P<.001, respectively). Lipid layers appeared lower for the MGD group than others.
CONCLUSIONS
Compared with controls, lid lipid levels are reduced in patients with MGD, and increased in women with AD. Lipid layer thickness is increased in women with AD compared with patients with MGD. Both meibometric techniques may be useful for evaluating MGD. Although DM requires special equipment (the Meibometer), it provides a record of immediate diagnostic value. Although IM is less effective than DM, it offers visual documentation of the lipid imprint, which may itself be of diagnostic value, and uses equipment available in many laboratories.
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影响因子：
4.4
作者：
J. Jester;N. Nicolaides;R. E. Smith
通讯作者：
J. Jester;N. Nicolaides;R. E. Smith
影响因子：
13.7
作者：
J. Robin;J. Jester;J. Nobe;Nicholas E. Nicolaides;Ronald E. Smith
通讯作者：
J. Robin;J. Jester;J. Nobe;Nicholas E. Nicolaides;Ronald E. Smith
蜡酯脂肪醇在慢性睑缘炎中的作用。
影响因子：
4.4
作者：
Shine,WE;McCulley,JP
通讯作者：
McCulley,JP
患有干燥性角结膜炎的眼睛泪液蒸发增加。
DOI：
10.1001/archopht.1983.01040010557003
发表时间：
1983
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Rolando,M;Refojo,MF;Kenyon,KR
通讯作者：
Kenyon,KR