Assessing cortisol from hair samples in a large observational cohort: The Whitehall II study.
Assessing cortisol from hair samples in a large observational cohort: The Whitehall II study.
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DOI：
10.1016/j.psyneuen.2016.07.214
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发表时间：
2016-11
影响因子：
3.7
通讯作者：
Kumari, Meena
中科院分区：
文献类型：
--
作者：
Abell, Jessica G.;Stalder, Tobias;Ferrie, Jane E.;Shipley, Martin J.;Kirschbaum, Clemens;Kivimaki, Mika;Kumari, Meena
头发样本为评估队列中的皮质醇提供了相当大的机会。某些头发特征与头发皮质醇浓度(Hcc)相关。心理和身体健康状况与肝细胞癌独立相关。头发皮质醇浓度(Hcc)被认为可以反映长期的综合皮质醇水平，但大多数与协变量相关的证据来自健康志愿者的小样本。这项研究的目的是描述在一项大型队列研究中收集头发样本的情况，并报告人口统计和健康指标与肝癌的相关性。我们检查了英国白厅II职业队列研究中3507名参与者(年龄59-83岁)头皮附近3厘米长的毛发部分测量的肝细胞癌。头发样品用柱切换LC-APCIMS/MS分析。相互调整的线性回归分析结果显示，报告使用染发剂的参与者的肝细胞癌较低[%差异(95%CI)；−12.5(−22.0，−1.9)，p值=0.022]，并有证据表明样本存储时间和季节变化的差异。就人口统计学变量而言，女性肝癌低于男性[−17.0(−24.8，−8.4，p值0.001)]，黑人高于其他种族。糖尿病的流行、全身皮质类固醇的使用和心血管药物的使用独立地与更高的肝细胞癌相关。在健康方面，在对身体疾病和药物进行调整后，抑郁症状与较高的肝细胞癌相关[20.0(8.1，33.3)，p值=0.001]。我们的结论是，头发类固醇分析为在大规模队列中评估皮质醇提供了重要机会。在未来的分析中，应该考虑人口统计因素、样本储存、采集季节和头发特征。精神和身体的健康状况与肝细胞癌有关。
Hair samples present considerable opportunities for assessing cortisol in cohorts. Certain hair characteristics correlate with hair cortisol concentrations (HCC). Mental and physical health status is independently associated with HCC. Hair cortisol concentrations (HCC) have been suggested to reflect long-term integrated cortisol levels, but most evidence of associations with co-variates is from small samples of healthy volunteers. The objective of this study was to describe the collection of hair samples in a large cohort study and report associations of demographic and health measures with HCC. We examined HCC measured from the 3 cm hair segment near the scalp in 3507 participants (aged 59–83 y) from The Whitehall II occupational cohort study of British civil servants. Hair samples were analysed using a column switching LC–APCI–MS/MS assay. Findings from mutually adjusted linear regression analyses revealed lower HCC in participants who reported use of hair dye [% difference (95%CI); −12.5 (−22.0, −1.9), p value = 0.022] and evidence suggestive of differences by length of sample storage and seasonal variation. With regard to demographic variables, HCC was lower in women compared to men [−17.0 (−24.8, −8.4), p value <0.001] and higher in Black compared to other ethnic groups. Prevalent diabetes, use of systemic corticosteroids and cardiovascular medication were independently associated with higher HCC. With regard to health, depressive symptoms were associated with higher HCC [20.0 (8.1, 33.3), p value = 0.001] following adjustment for physical disease and medication. We conclude that hair steroid analysis presents significant opportunities for assessing cortisol in large scale cohorts. Demographic factors, sample storage, season of collection and hair characteristics should be considered in future analyses. Health status, both mental and physical, is linked to HCC.
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影响因子：
5.8
作者：
Manenschijn, L.;Koper, J. W.;van Rossum, E. F. C.
通讯作者：
van Rossum, E. F. C.
影响因子：
3.7
作者：
Rippe, Ralph C. A.;Noppe, Gerard;van den Akker, Erica L. T.
通讯作者：
van den Akker, Erica L. T.
影响因子：
2.8
作者：
Raul, JS;Cirimele, V;Kintz, P
通讯作者：
Kintz, P
影响因子：
5.8
作者：
Manenschijn, L.;Schaap, L.;van Rossum, E. F. C.
通讯作者：
van Rossum, E. F. C.
DOI：
10.3109/10253890.2014.974028
发表时间：
2015-01-01
影响因子：
2.3
作者：
Boesch, Maria;Sefidan, Sandra;La Marca, Roberto
通讯作者：
La Marca, Roberto