Removal of high-fat diet after chronic exposure drives binge behavior and dopaminergic dysregulation in female mice.
Removal of high-fat diet after chronic exposure drives binge behavior and dopaminergic dysregulation in female mice.
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DOI：
10.1016/j.neuroscience.2016.04.002
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发表时间：
2016-06-21
期刊：
影响因子：
3.3
通讯作者：
Reyes TM
中科院分区：
文献类型：
--
作者：
Carlin JL;McKee SE;Hill-Smith T;Grissom NM;George R;Lucki I;Reyes TM
A significant contributor to the obesity epidemic is the overconsumption of highly palatable, energy dense foods. Chronic intake of palatable foods is associated with neuroadaptations within the mesocorticolimbic dopamine system adaptations which may lead to behavioral changes, such as overconsumption or bingeing. We examined behavioral and molecular outcomes in mice that were given chronic exposure to a high fat diet (HFD; 12 weeks), with the onset of the diet either in adolescence or adulthood. To examine whether observed effects could be reversed upon removal of the HFD, animals were also studied 4 weeks after a return to chow feeding. Most notably, female mice, particularly those exposed to HFD starting in adolescence, demonstrated the emergence of binge-like behavior when given restricted access to a palatable food. Further, changes in dopapmine-related gene expression and dopamine content in the prefrontal cortex were observed. Some of these HFD-drive phenotypes reversed upon removal of the diet, whereas others were initiated by removal of the diet. These findings have implications for obesity management and interventions, as both pharmacological and behavioral therapies are often combined with dietary interventions (e.g., reduction in calorie dense foods).
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影响因子：
2.9
作者：
Broft, Allegra I.;Berner, Laura A.;Martinez, Diana;Walsh, B. Timothy
通讯作者：
Walsh, B. Timothy
影响因子：
3.5
作者：
Babbs, R. K.;Unger, E. L.;Corwin, R. L. W.
通讯作者：
Corwin, R. L. W.
DOI：
10.1523/jneurosci.3237-12.2013
发表时间：
2013-04-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Halpern CH;Tekriwal A;Santollo J;Keating JG;Wolf JA;Daniels D;Bale TL
通讯作者：
Bale TL
影响因子：
2.3
作者：
Dess, NK;Badia-Elder, NE;Blizard, DA
通讯作者：
Blizard, DA
影响因子：
25
作者：
Johnson PM;Kenny PJ
通讯作者：
Kenny PJ