Association of cannabis use disorder with cardiovascular diseases: A two-sample Mendelian randomization study.
Association of cannabis use disorder with cardiovascular diseases: A two-sample Mendelian randomization study.
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DOI：
10.3389/fcvm.2022.966707
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发表时间：
2022
影响因子：
3.6
通讯作者：
Ma, Liang
中科院分区：
文献类型：
--
作者：
Chen, Miao;Lu, Yun-long;Chen, Xiao-fan;Wang, Zhen;Ma, Liang
关键词：
由于更多地区将用于治疗和娱乐目的的大麻合法化，全球大麻的使用量有所增加。几项观察性研究表明，大麻的使用与心血管疾病的风险增加有关。然而，大麻使用和心血管疾病之间的因果关系仍然不清楚。因此，我们进行了单变量和多变量孟德尔随机化(MR)来评估大麻使用障碍和各种心血管疾病之间的关联。摘要统计数据来自迄今为止最大规模的大麻使用障碍全基因组关联研究。本研究以大麻使用障碍的12个单核苷酸多态为工具变量。MR估计使用随机效应逆方差加权(IVW)方法合并。采用简单中位法和加权中位法进行敏感性分析。大麻使用障碍的遗传易感性与冠状动脉疾病、心肌梗死、房颤、心力衰竭、深静脉血栓形成、肺血栓和中风的风险增加有关。除卒中外，敏感度分析结果不一致。大麻使用障碍与房颤、心力衰竭、肺栓塞和中风的总体模式仍然存在于多变量MR分析中，这些分析调整了潜在的介质，包括吸烟、酒精、体重指数、血脂、2型糖尿病、高血压和抑郁症。然而，在多变量MR分析中，与冠状动脉疾病、心肌梗死和深静脉血栓形成的相关性并不持续。中介分析表明，吸烟、体重指数、低密度脂蛋白、高血压和抑郁有更显著的中介作用，这表明这些因素部分地中介了大麻使用障碍与冠状动脉疾病、心肌梗死和深静脉血栓形成的联系。大麻使用障碍的遗传易感性与房颤、心力衰竭、肺栓塞和中风的风险较高相关。大麻使用障碍、冠状动脉疾病、心肌梗死和深静脉血栓形成之间的联系的证据很弱。因此，今后出于治疗和娱乐目的使用大麻应考虑其对心血管疾病的潜在影响。
The use of cannabis has increased globally due to more regions decriminalizing marijuana use for therapeutic and recreational aims. Several observational studies have revealed that cannabis use is associated with an increased risk of adverse cardiovascular pathologies and diseases. Nevertheless, the causal associations between cannabis use and cardiovascular diseases remain unclear. Hence, we performed single-variable and multivariable Mendelian randomization (MR) to evaluate the association between cannabis use disorder and various cardiovascular diseases. Summary statistics were collected from the largest-to-date genome-wide association studies (GWAS) of cannabis use disorder. The 12 SNPs for cannabis use disorder were used as instrumental variables in this study. MR estimates were pooled using a random-effects inverse-variance weighted (IVW) method. Simple median and weighted median methods were conducted as sensitivity analyses. The genetic liability to cannabis use disorder was associated with an augmented risk of coronary artery disease, myocardial infarction, atrial fibrillation, heart failure, deep venous thrombosis, pulmonary embolism, and stroke. Except for stroke, the results were inconsistent in the sensitivity analyses. The overall patterns for the associations of cannabis use disorder with atrial fibrillation, heart failure, pulmonary embolism and stroke remained in multivariable MR analyses adjusting for potential mediators, including smoking, alcohol, body mass index, blood lipid, type 2 diabetes, hypertension, and depression. However, the association with coronary artery disease, myocardial infarction, and deep venous thrombosis did not persist in multivariable MR analyses. Mediation analysis demonstrated that smoking, body mass index, low-density lipoprotein, hypertension, and depression have more significant mediation effects, which suggests that these factors partly mediate the link from cannabis use disorder to coronary artery disease, myocardial infarction, and deep venous thrombosis. The genetic liability to cannabis use disorder was associated with a higher risk of atrial fibrillation, heart failure, pulmonary embolism, and stroke. The evidence for the association between cannabis use disorder, coronary artery disease, myocardial infarction, and deep venous thrombosis was weak. Hence, future use of cannabis for therapeutic and recreational aims should consider its potential impact on cardiovascular diseases.
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影响因子：
2
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan N;Thompson J
通讯作者：
Thompson J
可卡因和大麻在具有心肌梗塞的年轻人中使用。
影响因子：
24
作者：
DeFilippis EM;Singh A;Divakaran S;Gupta A;Collins BL;Biery D;Qamar A;Fatima A;Ramsis M;Pipilas D;Rajabi R;Eng M;Hainer J;Klein J;Januzzi JL;Nasir K;Di Carli MF;Bhatt DL;Blankstein R
通讯作者：
Blankstein R
DOI：
10.1097/ede.0000000000000559
发表时间：
2017-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Burgess S;Bowden J;Fall T;Ingelsson E;Thompson SG
通讯作者：
Thompson SG
影响因子：
3.8
作者：
Haleem, Ahmed;Hwang, Yoseob Joseph;Imtiaz, Sameer
通讯作者：
Imtiaz, Sameer
影响因子：
7.8
作者：
Carvalho, Andre F.;Stubbs, Brendon;Koyanagi, Ai
通讯作者：
Koyanagi, Ai