Functions and Mechanisms of Lysine Glutarylation in Eukaryotes.
Functions and Mechanisms of Lysine Glutarylation in Eukaryotes.
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DOI：
10.3389/fcell.2021.667684
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发表时间：
2021
影响因子：
5.5
通讯作者：
Qian K
中科院分区：
文献类型：
--
作者：
Xie L;Xiao Y;Meng F;Li Y;Shi Z;Qian K
赖氨酸戊二酰化（Kglu）是一种新发现的翻译后修饰（PTM），在原核生物和真核生物中被认为是可逆的、动态的和保守的。近年来通过质谱鉴定KGlu的研究表明，KGlu主要参与代谢、氧化损伤、染色质动力学的调节，并与多种疾病相关。本文首先综述了戊二酰化反应的发展历史、戊二酰化和脱戊二酰化的生化过程。然后，我们专注于病理生理功能，如谷氨酸血症1，弱精子症等，最后，目前的计算工具预测戊二酰化位点进行了讨论。这些新的发现指出了赖氨酸戊二酰化和相关酶的新功能，并强调了戊二酰化调节不同细胞过程的机制。
Lysine glutarylation (Kglu) is a newly discovered post-translational modification (PTM), which is considered to be reversible, dynamic, and conserved in prokaryotes and eukaryotes. Recent developments in the identification of Kglu by mass spectrometry have shown that Kglu is mainly involved in the regulation of metabolism, oxidative damage, chromatin dynamics and is associated with various diseases. In this review, we firstly summarize the development history of glutarylation, the biochemical processes of glutarylation and deglutarylation. Then we focus on the pathophysiological functions such as glutaric acidemia 1, asthenospermia, etc. Finally, the current computational tools for predicting glutarylation sites are discussed. These emerging findings point to new functions for lysine glutarylation and related enzymes, and also highlight the mechanisms by which glutarylation regulates diverse cellular processes.
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