Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion.
Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion.
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DOI：
10.3390/toxins7041079
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发表时间：
2015-03-27
期刊：
影响因子：
4.2
通讯作者：
De Waard M
中科院分区：
文献类型：
--
作者：
Dardevet L;Rani D;Aziz TA;Bazin I;Sabatier JM;Fadl M;Brambilla E;De Waard M
Chlorotoxin是一种由36个氨基酸组成的小肽，从五纹蝎Leiurus quinquestriatus的毒液中鉴定出来。最初，氯毒素被用作表征氯离子通道的药理学工具。在研究神经胶质瘤特异性氯电流时，很快发现氯毒素对包括神经胶质瘤、黑色素瘤、小细胞肺癌、神经母细胞瘤和髓母细胞瘤的癌细胞具有靶向性质。氯毒素作用机制的研究一直具有挑战性，因为其细胞表面受体靶点仍受到质疑，因为除了氯离子通道外，还有两种其他受体。基于氯毒素的应用的努力集中在生产有助于神经胶质瘤诊断、成像和治疗的类似物上。这些努力是受欢迎的，因为神经胶质瘤是非常具有侵袭性的脑癌，几乎不可能用目前的治疗手段治愈。在所有基于氯毒素的策略中，最有希望提高患者平均生存时间的策略似乎是使用氯毒素作为靶向剂用于递送抗肿瘤剂。最后，氯毒素的发现导致了对其他蝎子毒液的筛选，以鉴定氯毒素样肽。到目前为止，已经确定了几个新的候选人。只有详细的研究和临床调查才能告诉我们它们是否具有与氯毒素相同的抗肿瘤潜力。
Chlorotoxin is a small 36 amino-acid peptide identified from the venom of the scorpion Leiurus quinquestriatus. Initially, chlorotoxin was used as a pharmacological tool to characterize chloride channels. While studying glioma-specific chloride currents, it was soon discovered that chlorotoxin possesses targeting properties towards cancer cells including glioma, melanoma, small cell lung carcinoma, neuroblastoma and medulloblastoma. The investigation of the mechanism of action of chlorotoxin has been challenging because its cell surface receptor target remains under questioning since two other receptors have been claimed besides chloride channels. Efforts on chlorotoxin-based applications focused on producing analogues helpful for glioma diagnosis, imaging and treatment. These efforts are welcome since gliomas are very aggressive brain cancers, close to impossible to cure with the current therapeutic arsenal. Among all the chlorotoxin-based strategies, the most promising one to enhance patient mean survival time appears to be the use of chlorotoxin as a targeting agent for the delivery of anti-tumor agents. Finally, the discovery of chlorotoxin has led to the screening of other scorpion venoms to identify chlorotoxin-like peptides. So far several new candidates have been identified. Only detailed research and clinical investigations will tell us if they share the same anti-tumor potential as chlorotoxin.
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影响因子：
14.9
作者：
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影响因子：
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影响因子：
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作者：
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