Human IgE-independent systemic anaphylaxis.
Human IgE-independent systemic anaphylaxis.
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DOI：
10.1016/j.jaci.2016.02.015
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Strait R
中科院分区：
文献类型：
--
作者：
Finkelman FD;Khodoun MV;Strait R
过敏反应是一种快速发展的、危及生命的全身性或全身性过敏反应，通常由与肥大细胞和嗜碱性粒细胞上的高亲和力IgE受体FcεRI结合的Ag特异性IgE的抗原（Ag）交联引起。这引发诱导细胞脱粒的信号，伴随血管活性介质、酶和细胞因子的释放和分泌。然而，过敏反应的IgE非依赖性机制已在实验动物中得到明确证明。这些包括IgG依赖性过敏反应，其涉及通过IgG/抗原复合物交联巨噬细胞、嗜碱性粒细胞和中性粒细胞上的Fcγ R触发介质释放;补体衍生肽C3 a和C5 a与肥大细胞、嗜碱性粒细胞和其他骨髓细胞上的受体结合介导的过敏反应;以及通过与这些细胞上的受体相互作用的药物直接激活肥大细胞。在这里，我们回顾了这些IgE非依赖性形式的过敏反应的机制和临床证据，其人类的相关性。我们的结论是，这一证据支持存在的所有三个IgE非依赖性机制作为人类疾病的重要原因，虽然实际和伦理的考虑排除他们的演示程度的确定性可能与动物模型。此外，我们引用的证据表明，不同的临床情况可以表明不同的机制作为过敏反应的主要作用，IgE依赖性和不同的IgE非依赖性机制可以共同作用，以增加过敏反应的严重程度。随着可以干扰不同类型过敏反应机制的特定药物的出现，识别特定类型的过敏反应对于最佳预防和治疗可能变得重要。
Anaphylaxis is a rapidly developing, life-threatening, generalized or systemic allergic reaction that is classically elicited by antigen (Ag) crosslinking of Ag-specific IgE bound to the high affinity IgE receptor, FcεRI, on mast cells and basophils. This initiates signals that induce cellular degranulation, with release and secretion of vasoactive mediators, enzymes, and cytokines. IgE-independent mechanisms of anaphylaxis, however, have been clearly demonstrated in experimental animals. These include IgG-dependent anaphylaxis, which involves the triggering of mediator release by IgG/antigen complex crosslinking of FcγRs on macrophages, basophils and neutrophils; anaphylaxis mediated by the binding of complement-derived peptides, C3a and C5a, to their receptors on mast cells, basophils and other myeloid cells; and direct activation of mast cells by drugs that interact with receptors on these cells. Here, we review the mechanisms involved in these IgE-independent forms of anaphylaxis and the clinical evidence for their human relevance. We conclude that this evidence supports the existence of all three IgE-independent mechanisms as important causes of human disease, although practical and ethical considerations preclude their demonstration to the degree of certainty possible with animal models. Further, we cite evidence that different clinical situations can suggest different mechanisms as having a primal role in anaphylaxis and that IgE-dependent and distinct IgE-independent mechanisms can act together to increase anaphylaxis severity. As specific agents become available that can interfere with mechanisms involved in the different types of anaphylaxis, recognition of specific types of anaphylaxis is likely to become important for optimal prophylaxis and therapy.
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影响因子：
14.2
作者：
Khodoun, Marat V.;Kucuk, Zeynep Yesim;Finkelman, Fred D.
通讯作者：
Finkelman, Fred D.
影响因子：
64.8
作者：
McNeil, Benjamin D.;Pundir, Priyanka;Meeker, Sonya;Han, Liang;Undem, Bradley J.;Kulka, Marianna;Dong, Xinzhong
通讯作者：
Dong, Xinzhong
影响因子：
15.9
作者：
Brandt, EB;Strait, RT;Rothenberg, ME
通讯作者：
Rothenberg, ME
DOI：
10.1016/j.jaci.2012.03.004
发表时间：
2012-05
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Kucuk ZY;Strait R;Khodoun MV;Mahler A;Hogan S;Finkelman FD
通讯作者：
Finkelman FD
影响因子：
14.2
作者：
Khodoun, Marat;Strait, Richard;Orekov, Tatyana;Hogan, Simon;Karasuyama, Hajime;Herbert, De'Broski R.;Koehl, Joerg;Finkelman, Fred D.
通讯作者：
Finkelman, Fred D.